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Kinesin-Like Protein KIF2C

Known as: Mitotic Centromere-Associated Kinesin, KIF2C, MCAK 
Kinesin-like protein KIF2C (725 aa, ~81 kDa) is encoded by the human KIF2C gene. This protein is involved in tubulin depolymerization.
National Institutes of Health

Related topics

Related topics

11 relations
Cellular MembraneCentromereChromosome SegregationKIF2C gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR‐325‐3p
Nonsmall cell lung cancer (NSCLC) is one of the leading causes of cancer‐related death worldwide. Kinesin family member 2C (KIF2C… 
Highly Cited
2017
Highly Cited
2017
Kinesin superfamily protein expression and its association with progression and prognosis in hepatocellular carcinoma.
OBJECTIVES In this study, we characterized the expression of 32 other kinesin superfamily proteins (KIFs) and analyzed their… 
Highly Cited
2013
Highly Cited
2013
Aurora B Inhibits MCAK Activity through a Phosphoconformational Switch that Reduces Microtubule Association
Highly Cited
2011
Highly Cited
2011
The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization
Unlike other kinesins, members of the kinesin‐13 subfamily do not move directionally along microtubules but, instead… 
2011
2011
Kinesin-Like Protein 6 (KIF6) Polymorphism and the Efficacy of Rosuvastatin in Primary Prevention
Background— Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6 ) 719 arginine… 
Highly Cited
2009
Highly Cited
2009
Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK
The kinesin-13, MCAK, is a critical regulator of microtubule dynamics in eukaryotic cells. We have functionally dissected the… 
Highly Cited
2008
Highly Cited
2008
Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
Highly Cited
2008
Highly Cited
2008
Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.
Highly Cited
2005
Highly Cited
2005
Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK.
MCAK belongs to the Kinesin-13 family, whose members depolymerize microtubules rather than translocate along them. We defined the… 
Highly Cited
2004
Highly Cited
2004
Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity
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