Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.

@article{Iakoubova2008AssociationOT,
  title={Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.},
  author={Olga A. Iakoubova and Carmen H Tong and Charles M. Rowland and Todd G. Kirchgessner and Bradford A. Young and Andre R. Arellano and Dov Shiffman and Marc S. Sabatine and Hannia Campos and Christopher J. Packard and Marc Pfeffer and Thomas J. White and Eugene Braunwald and James Michael Shepherd and James J. Devlin and Frank M. Sacks},
  journal={Journal of the American College of Cardiology},
  year={2008},
  volume={51 4},
  pages={435-43}
}
OBJECTIVES We asked whether 35 genetic polymorphisms, previously found to be associated with cardiovascular disease, were associated with myocardial infarction (MI) in the CARE (Cholesterol and Recurrent Events) trial and with coronary heart disease (CHD) in the WOSCOPS (West of Scotland Coronary Prevention Study) trial and whether the risk associated with these polymorphisms could be reduced by pravastatin treatment. BACKGROUND Identification of genetic polymorphisms associated with CHD may… CONTINUE READING
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