D. Chasman
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- Publications
- Influence
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- E. K. Speliotes, C. Willer, +372 authors R. Loos
- Biology
- 2010
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between… Expand
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Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
- Tanya M. Teslovich, K. Musunuru, +206 authors S. Kathiresan
- Biology, Medicine
- Nature
- 5 August 2010
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery… Expand
Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, +479 authors E. K. Speliotes
- Biology, Medicine
- Nature
- 12 February 2015
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… Expand
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, E. Schmidt, +256 authors G. Abecasis
- Medicine, Biology
- Nature Genetics
- 6 October 2013
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery… Expand
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, +442 authors T. Frayling
- Biology, Medicine
- Nature Genetics
- 8 September 2014
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different… Expand
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
- K. Estrada, U. Styrkarsdottir, +178 authors F. Rivadeneira
- Biology, Medicine
- Nature Genetics
- 9 April 2012
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide… Expand
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
- Anna Köttgen, E. Albrecht, +222 authors C. Gieger
- Medicine, Biology
- Nature Genetics
- 1 February 2013
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics… Expand
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, +403 authors K. Mohlke
- Biology, Medicine
- Nature
- 16 December 2014
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body… Expand
Hundreds of variants clustered in genomic loci and biological pathways affect human height
- H. Lango Allen, K. Estrada, +290 authors J. Hirschhorn
- Biology, Medicine
- Nature
- 10 August 2010
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have… Expand
Efficient Bayesian mixed model analysis increases association power in large cohorts
Linear mixed models are a powerful statistical tool for identifying genetic associations and avoiding confounding. However, existing methods are computationally intractable in large cohorts, and may… Expand