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A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission.
Evidence is presented that performance measures can validly characterize older persons across a broad spectrum of lower extremity function and that performance and self-report measures may complement each other in providing useful information about functional status.
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Antiinflammatory therapy targeting the interleukin‐1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid‐level lowering.
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.
Variable selection for propensity score models.
- M. Brookhart, S. Schneeweiss, K. Rothman, R. Glynn, J. Avorn, T. Stürmer
- PsychologyAmerican journal of epidemiology
- 15 June 2006
The authors present the results of two simulation studies designed to help epidemiologists gain insight into the variable selection problem in a PS analysis, which suggest that standard model-building tools designed to create good predictive models of the exposure will not always lead to optimal PS models, particularly in small studies.
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect.
Observational studies often provide the only available information about treatment effects. Control of confounding, however, remains challenging. The authors compared five methods for evaluating the…
High-dimensional Propensity Score Adjustment in Studies of Treatment Effects Using Health Care Claims Data
- S. Schneeweiss, J. Rassen, R. Glynn, J. Avorn, H. Mogun, M. Brookhart
- 1 July 2009
In typical pharmacoepidemiologic studies, the proposed high-dimensional propensity score resulted in improved effect estimates compared with adjustment limited to predefined covariates, when benchmarked against results expected from randomized trials.
Reduction of bacteriuria and pyuria after ingestion of cranberry juice.
It is suggested that use of a cranberry beverage reduces the frequency of bacteriuria with pyuria in older women and prevalent beliefs about the effects of cranberry juice on the urinary tract may have microbiologic justification.
Full coverage for preventive medications after myocardial infarction.
- N. Choudhry, J. Avorn, W. Shrank
- Medicine, Political ScienceThe New England journal of medicine
- 30 November 2011
BACKGROUND Adherence to medications that are prescribed after myocardial infarction is poor. Eliminating out-of-pocket costs may increase adherence and improve outcomes. METHODS We enrolled…