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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations betweenExpand
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Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary arteryExpand
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Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body massExpand
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C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.
BACKGROUND Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the predictionExpand
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Inflammation and Atherosclerosis
Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an ongoing inflammatory response. Recent advances in basic science have established a fundamental role forExpand
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Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
BACKGROUND Inflammation may be important in the pathogenesis of atherothrombosis. We studied whether inflammation increases the risk of a first thrombotic event and whether treatment with aspirinExpand
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C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.
CONTEXT Inflammation is hypothesized to play a role in development of type 2 diabetes mellitus (DM); however, clinical data addressing this issue are limited. OBJECTIVE To determine whetherExpand
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Progress and challenges in translating the biology of atherosclerosis
Atherosclerosis is a chronic disease of the arterial wall, and a leading cause of death and loss of productive life years worldwide. Research into the disease has led to many compelling hypothesesExpand
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Clinical application of C-reactive protein for cardiovascular disease detection and prevention.
In an attempt to improve global cardiovascular risk prediction, considerable interest has focused on C-reactive protein (CRP), a marker of inflammation that has been shown in multiple prospectiveExpand
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Discovery and Refinement of Loci Associated with Lipid Levels
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary arteryExpand
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