H. Osada

Publications741
h-index63
Citations16,001
Highly Influential Citations429
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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.
TLDR
The analysis indicates that beta-TrCP-dependent degradation of Wee1A is important for the normal onset of M-phase in vivo and establishes the existence of a feedback loop between Cdc2 and Wee 1A in somatic cells that depends on ubiquitination and protein degradation and ensures the rapid activation of CDC2 when cells are ready to divide.
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In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation
TLDR
It is suggested that acetylation and deacetylation are coupled to the microtubule turnover and that HDAC6 plays a key regulatory role in the stability of the dynamic microtubules.
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Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.
TLDR
It is shown that the phosphorylation-dependent degradation of Wee1A is important for the proper onset of mitosis.
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Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils.
TLDR
Examining cellulose microfibril regeneration using taxol-treated protoplasts revealed that the cobtorin compound perturbed the parallel alignment of pre-existing cortical microtubules and nascent cellulosemicrofibrils, suggesting strong binding activity to the putative target.
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RECK negatively regulates matrix metalloproteinase-9 transcription.
TLDR
The gene expression profiles between mock- and RECK-transfected HT1080 cells were compared and showed that RECK decreases MMP-9 mRNA levels but not other MMP mRNA levels, and that RECk is a negative regulator of M MP-9 transcription.
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Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.
TLDR
Two new protein phosphatase inhibitors, oscillamide B and C, were isolated from the cyanobacteria Planktothrix (Oscillatoria) agardhii and P. rubescens and elucidated by analysis of HRFABMS, 1D and 2D NMR spectra, and chemical degradation.
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Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis
TLDR
It is shown that tumor necrosis factor alpha induced RIP-dependent inhibition of adenine nucleotide translocase (ANT)-conducted transport of ADP into mitochondria, which resulted in reduced ATP and necrotic cell death.
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The phosphorylation status and anti‐apoptotic activity of Bcl‐2 are regulated by ERK and protein phosphatase 2A on the mitochondria
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Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition*
TLDR
The predominant role of PBD-dependent binding on smooth chromosome congression at metaphase is demonstrated and the high-throughput screening system developed shows it to be essential for Plk1 localization and substrate targeting.
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Activation of p38 mitogen‐activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor
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