Microsomes

Known as: Endoplasmic reticulum vesicle, Microsome 
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are… (More)

Topic mentions per year

Topic mentions per year

1944-2017
0500100019442016

Papers overview

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Highly Cited
2000
Highly Cited
2000
The UDP-glucuronosyltransferases (UGTs) are a superfamily of membrane-bound enzymes whose active site is localized inside the… (More)
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Highly Cited
1999
Highly Cited
1999
  • Rossend Obach
  • Drug metabolism and disposition: the biological…
  • 1999
Twenty-nine drugs of disparate structures and physicochemical properties were used in an examination of the capability of human… (More)
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Highly Cited
1999
Highly Cited
1999
The purpose of this study was to compare the kinetics of intestinal and hepatic cytochrome P-450 3A (CYP3A) inhibition by using… (More)
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Highly Cited
1997
Highly Cited
1997
  • Rossend Obach
  • Drug metabolism and disposition: the biological…
  • 1997
The nonspecific, noncovalent binding of three drugs, imipramine, warfarin, and propranolol, to pooled human and animal liver… (More)
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Highly Cited
1997
Highly Cited
1997
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of variation in the metabolism of nicotine… (More)
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Highly Cited
1996
Highly Cited
1996
Cytochrome P450 chemical inhibitors are widely used to define the role of individual cytochrome P450 isozyme(s) in a metabolism… (More)
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Highly Cited
1994
Highly Cited
1994
Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30… (More)
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Highly Cited
1993
Highly Cited
1993
The present study identifies the specific human cytochrome P-450 (CYP) enzymes involved in hydroxylation leading to activation of… (More)
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Highly Cited
1988
Highly Cited
1988
Liver slices were used to measure lipid peroxidation induced by bromotrichloromethane, tert-butyl hydroperoxide (t-BOOH), or… (More)
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Highly Cited
1964
Highly Cited
1964
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by… (More)
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