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An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels.
3,3′,5,5′-tetramethylbenzidine-H2O2 as a stain for the peroxidase activity of cytochrome P-450 in sodium dodecyl sulfate polyacrylamide gels can be used to detect very low levels of heme-associated peroxIDase activity. Expand
Purification and characterization of hepatic microsomal cytochrome P-450.
Article de synthese sur le cytochrome P450, sa purification et la caracterisation de ses proprietes structurales (electrophorese gel), immunologiques, metaboliques (activite enzymatique). Axe sur leExpand
PCBs: structure–function relationships and mechanism of action
There was an excellent correlation between AHH induction potencies and receptor binding avidities of these compounds and the order of activity was coplanar PCBs, the halogenated aromatic hydrocarbons which exhibit the highest binding affinities for the receptor protein. Expand
Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats.
The studies show that constitutive expression and induction of steroid-inducible cytochrome P450s may vary as a function of age. Expand
Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to be determined for a GTP-dependentExpand
Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.
Cytochrome P-450j has been purified to electrophoretic homogeneity from isoniazid-treated adult male rats; and this enzyme appears to be a major protein induced in hepatic microsomes afterExpand
Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.
  • A. Y. Lu, W. Levin
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 16 February 1972
Cytochromes P-450 and P-448 were solubilized and partially purified from rat liver microsomes and exhibited different substrate specificities for benzphetamine and 3,4-benzpyrene. Expand
A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage.
This is the first report of a potent selective PRL inhibitor that suppresses tumor cell three-dimensional growth by a novel mechanism involving p130Cas cleavage, and shows that PRL may represent an attractive target for therapeutic intervention in cancer. Expand
Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.
Twelve structurally diverse xenobiotics have been examined for their capacity to modulate the levels of cytochrome P-450d, as well as cytochromes P -450a, P- 450b, and P-550c, in rat liver microsomes, suggesting that the inducibility of these cyto Chrome P-451 isozymes, but not cyto Chromes P-475a and P.450b, is linked. Expand
Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin.
The results suggest that the masculinization of expression of these two sexually dimorphic isozymes of cytochrome P450 may occur by different mechanisms, and that phenytoin is atypical of the other nine compounds the authors tested. Expand