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An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels.
Purification and characterization of hepatic microsomal cytochrome P-450.
PCBs: structure–function relationships and mechanism of action
There was an excellent correlation between AHH induction potencies and receptor binding avidities of these compounds and the order of activity was coplanar PCBs, the halogenated aromatic hydrocarbons which exhibit the highest binding affinities for the receptor protein.
A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage.
This is the first report of a potent selective PRL inhibitor that suppresses tumor cell three-dimensional growth by a novel mechanism involving p130Cas cleavage, and shows that PRL may represent an attractive target for therapeutic intervention in cancer.
Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats.
The studies show that constitutive expression and induction of steroid-inducible cytochrome P450s may vary as a function of age.
Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
We report crystal structures of the human enzyme phosphoenolpyruvate carboxykinase (PEPCK) with and without bound substrates. These structures are the first to be determined for a GTP-dependent…
Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.
Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.
Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.
Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin.
- A. Ghosal, N. Sadrieh, L. Reik, W. Levin, P. Thomas
- BiologyArchives of biochemistry and biophysics
- 1 August 1996
The results suggest that the masculinization of expression of these two sexually dimorphic isozymes of cytochrome P450 may occur by different mechanisms, and that phenytoin is atypical of the other nine compounds the authors tested.