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Microsomes, Liver

Known as: Liver Microsome, Liver Microsomes, Microsome, Liver 
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
National Institutes of Health

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Related topics

7 relations
LiverLiver-kidney microsomal antibodyMicrobiologicalProcess of secretion
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Broader (1)

Microsomes

Papers overview

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Highly Cited
2004
Highly Cited
2004
Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes
Polyunsaturated fatty acids (PUFA) are vulnerable to peroxidative attack. Protecting PUFA from peroxidation is essential to… Expand
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Highly Cited
2003
Highly Cited
2003
Pigments of rat liver microsomes.
Abstract The total hemin content of washed rat liver microsomes is 2.15 times the cytochrome b5 content, only a small part being… Expand
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Highly Cited
2001
Highly Cited
2001
Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
We investigated the quantitative prediction of human hepatic metabolic clearance from in vitro experiments focusing on cytochrome… Expand
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Highly Cited
1997
Highly Cited
1997
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.
Nicotine is primarily metabolized to cotinine by cytochromes P450 (CYPs). The degree of variation in the metabolism of nicotine… Expand
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Highly Cited
1995
Highly Cited
1995
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… Expand
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Highly Cited
1990
Highly Cited
1990
Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes.
Rat liver microsomes were irradiated with gamma-rays at a dose rate of 1.31 Gys-1. The extent of lipid peroxidation, measured in… Expand
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Highly Cited
1990
Highly Cited
1990
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many… Expand
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Highly Cited
1964
Highly Cited
1964
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by… Expand
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Highly Cited
1964
Highly Cited
1964
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by… Expand
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Highly Cited
1962
Highly Cited
1962
A new cytochrome in liver microsomes.
8. HEPPEL, L. A., in S. P. COLOWICK AND N. 0. KAPLAN (Editors), Methods in enzymology, Vol. II, Academic Press, Inc., New York… Expand
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