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Microsomes, Liver

Known as: Liver Microsome, Liver Microsomes, Microsome, Liver 
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
National Institutes of Health

Related topics

Related topics

7 relations
LiverLiver-kidney microsomal antibodyMicrobiologicalProcess of secretion
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Broader (1)

Microsomes

Papers overview

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Highly Cited
1995
Highly Cited
1995
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… Expand
Highly Cited
1993
Highly Cited
1993
Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.
Acetaminophen (APAP), a commonly used analgesic, is catalyzed by cytochrome P450 (P450) enzymes to a toxic intermediate which can… Expand
Highly Cited
1990
Highly Cited
1990
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many… Expand
Highly Cited
1990
Highly Cited
1990
Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes.
Rat liver microsomes were irradiated with gamma-rays at a dose rate of 1.31 Gys-1. The extent of lipid peroxidation, measured in… Expand
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Highly Cited
1982
Highly Cited
1982
Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes.
1. Methods using t.l.c. and high-pressure liquid chromatography (h.p.l.c.) have been used to separate the complex variety of… Expand
Highly Cited
1975
Highly Cited
1975
Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes.
Summary Calf-liver rough microsomes incorporated N-acetyl[3H] glucosamine from UDP-[3H]GlcNAc or [14C]mannose from GDP-[14C]Man… Expand
Highly Cited
1967
Highly Cited
1967
AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA
Preparations of rat-liver mitochondria catalyze the oxidation of exogenous NADH by added cytochrome c or ferricyanide by a… Expand
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Highly Cited
1964
Highly Cited
1964
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by… Expand
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Highly Cited
1964
Highly Cited
1964
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by… Expand
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Highly Cited
1962
Highly Cited
1962
A new cytochrome in liver microsomes.
  • T. Omura, R. Sato
  • The Journal of biological chemistry
  • 1962
    • Corpus ID: 38102151
8. HEPPEL, L. A., in S. P. COLOWICK AND N. 0. KAPLAN (Editors), Methods in enzymology, Vol. II, Academic Press, Inc., New York… Expand
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