FAQ

Microsomes, Liver

Known as: Liver Microsome, Liver Microsomes, Microsome, Liver 
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
0204019512017

Related topics

Related topics

7 relations
LiverLiver-kidney microsomal antibodyMicrobiologicalProcess of secretion
(More)

Broader (1)

Microsomes

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Microsomes, Liver
physiological aspects
Liver
Microsomes
Microbiological
Process of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Stereoselective Metabolism of Bupropion by Cytochrome P4502B6 (CYP2B6) and Human Liver Microsomes
Hydroxylation of the antidepressant and smoking deterrent drug bupropion is a clinically important bioactivation and elimination… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table I
Is this relevant?
2006
2006
Predictions of the In Vivo Clearance of Drugs from Rate of Loss Using Human Liver Microsomes for Phase I and Phase II Biotransformations
The utility of in vitro metabolism to accurately predict the clearance of hepatically metabolized drugs was evaluated. Three… (More)
  • table I
  • figure 1
  • table II
  • table III
  • table IV
Is this relevant?
2006
2006
Cyp4f Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-demethylation of the Antiparasitic Prodrug Db289
Primary laboratory of origin: Division of Molecular Pharmaceutics, School of Pharmacy, The University of North Carolina at Chapel… (More)
  • table 1
  • table 2
Is this relevant?
2004
2004
Potential Beneficial Metabolic Interactions Between Tamoxifen and Isoflavones via Cytochrome P450-mediated Pathways in Female Rat Liver Microsomes
Purpose. This study aims to evaluate a cytochrome P450-based tamoxifen-isoflavone interaction and to determine the mechanisms… (More)
  • figure 2
  • figure 1
  • figure 3
  • table I
  • figure 4
Is this relevant?
2002
2002
In Vitro Characterization of Hepatic Flavopiridol Metabolism Using Human Liver Microsomes and Recombinant UGT Enzymes
Purpose. To assess the contribution of drug metabolism to the variability on flavopiridol glucuronidation observed in cancer… (More)
  • figure 1
  • figure 2
  • table I
  • figure 3
  • table II
Is this relevant?
2000
2000
Prediction of In Vivo Interaction Between Triazolam and Erythromycin Based on In Vitro Studies Using Human Liver Microsomes and Recombinant Human CYP3A4
Purpose. To quantitatively predict the in vivo interaction betweentriazolam and erythromycin, which involves mechanism… (More)
  • figure 1
  • table 1
  • figure 3
  • figure 2
  • table 2
Is this relevant?
1999
1999
O- and N-demethylation of Venlafaxine In Vitro by Human Liver Microsomes and by Microsomes from cDNA-Transfected Cells: Effect of Metabolic Inhibitors and SSRI Antidepressants
The biotransformation of venlafaxine (VF) into its two major metabolites, O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
1971
1971
Bilirubin Uridine Diphospho-glucuronyltransferase in Rat Liver Microsomes: Genetic Variation and Maturation
Extract: Optimal conditions for the in vitro assay of bilirubin uridine diphospho- (UDP) glu-curonyltransferase activity in rat… (More)
  • table I
  • figure 1
  • figure 4
  • figure 7
  • figure 6
Is this relevant?
Highly Cited
1964
Highly Cited
1964
The Carbon Monoxide-binding Pigment of Liver Microsomes. I. Evidence for Its Hemoprotein Nature.
The presence in mammalian liver microsomes of a carbon monoxide-binding pigment has been reported by Klingenberg (1) and by… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table I
Is this relevant?
Highly Cited
1964
Highly Cited
1964
The Carbon Monoxide-binding Pigment of Liver Microsomes. Ii. Solubilization, Purification, and Properties.
 
Is this relevant?