• Publications
  • Influence
Degradation of steroids in the human gut.
  • 298
  • 8
Vaccinia as a model for membrane biogenesis.
Abstract The biogenesis of vaccinia envelopes was examined by combined chemical and electron microscopic procedures. These lipoprotein membranes develop within discrete viroplasmic foci, initiallyExpand
  • 228
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Bile acid biosynthesis
This review summarizes certain biochemical aspects of bile acid biosynthesis. It is pointed out that our knowledge of the biosynthetic pathway is still incomplete. The significance of alternateExpand
  • 137
  • 6
Regulation of bile acid synthesis.
  • E. Mosbach
  • Chemistry, Medicine
  • Verhandlungen der Deutschen Gesellschaft fur…
  • 1974
Bile acids formed from cholesterol in the liver are defined as “primary” bile acids. In man, these are chenodeoxycholic acid and cholic acid. Following conjugation with glycine or taurine the bileExpand
  • 126
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Feedback regulation of bile acid biosynthesis in the rat.
The hepatic biosynthesis of bile salts in the rat has been shown to be controlled homeostatically by the quantity of bile salt returning to the liver via the portal circulation. The feedbackExpand
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Inborn errors of bile acid synthesis.
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Biochemical site of regulation of bile acid biosynthesis in the rat.
The production of bile salts by rat liver is regulated by a feedback mechanism, but it is not known which enzyme controls endogenous bile acid synthesis. In order to demonstrate the biochemical siteExpand
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A biochemical abnormality in cerebrotendinous xanthomatosis. Impairment of bile acid biosynthesis associated with incomplete degradation of the cholesterol side chain.
Bile acid production in cerebrotendinous xanthomatosis (CTX) is subnormal, yet the activity of cholesterol 7alpha-hydroxylase, the rate-determining enzyme of bile acid synthesis, is elevated. ToExpand
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  • PDF
Regulatory effects of dietary sterols and bile acids on rat intestinal HMG CoA reductase.
The specific activity (concentration) of microsomal HMG CoA reductase of intestinal crypt cells was studied in rats fed sterols and bile acids, either singly or in combination. It was found that theExpand
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Mode of action of steroid desmolase and reductases synthesized by Clostridium "scindens" (formerly Clostridium strain 19).
A recently isolated hitherto unknown Clostridium from human feces, designated Clostridium "scindens" (formerly strain 19), synthesizes at least two enzymes active on the side-chain of the steroidExpand
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