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Regulation of bile acid synthesis.
  • E. Mosbach
  • Chemistry, Biology
    Verhandlungen der Deutschen Gesellschaft fur…
  • 1974
Bile acids formed from cholesterol in the liver are defined as “primary” bile acids, which are secreted into the bile and stored in the gallbladder before participating in the intestinal digestive process.
Feedback regulation of bile acid biosynthesis in the rat.
The feedback mechanism was demonstrated in two kinds of experiments where rats with bile fistulas were infused intraduodenally with sodium taurocholate and the rate of infusion exceeded 10 mg per 100 g rat per hr, and bile acid secretion returned to the low levels observed in intact rats.
Bile acid biosynthesis
  • E. Mosbach, G. Salen
  • Biology, Chemistry
    The American Journal of Digestive Diseases
  • 1 October 1974
This review summarizes certain biochemical aspects of bile acid biosynthesis that are defective in cerebrotendinous xanthomatosis (CTX), a rare, familial sterol storage disease.
Inborn errors of bile acid synthesis.
A biochemical abnormality in cerebrotendinous xanthomatosis. Impairment of bile acid biosynthesis associated with incomplete degradation of the cholesterol side chain.
The accumulation of alcohols hydroxylated at C-25 and C-24,25 suggests that decreased bile acid synthesis in CTX results from impaired oxidation of the cholesterol side chain, and current views of the major pathway of bile Acid synthesis may require revision.
Biochemical site of regulation of bile acid biosynthesis in the rat.
Results indicate that the regulation of bile acid biosynthesis is exerted via cholesterol 7alpha-hydroxylase provided that hepatic cholesterol synthesis is adequate.
Regulatory effects of dietary sterols and bile acids on rat intestinal HMG CoA reductase.
The results indicate that dietary sterols and bile acids both play a role in the regulation of intestinal HMG CoA reductase, and are associated with an increase in sterol concentration within the intestinal crypt cells.
Mode of action of steroid desmolase and reductases synthesized by Clostridium "scindens" (formerly Clostridium strain 19).
A recently isolated hitherto unknown Clostridium from human feces, designated Clostridium "scindens" (formerly strain 19), synthesizes at least two enzymes active on the side-chain of the steroid