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Metabolism and function of coenzyme Q.
Biochemical, physiological and medical aspects of ubiquinone function.
Coenzyme Q--biosynthesis and functions.
Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders.
2 novel inborn errors of CoQ10 biosynthesis in 2 distinct families are identified, indicating that these mutations are indeed the cause of OXPHOS deficiency.
Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.
- Z. Guan, Y. Wang, N. Cairns, P. Lantos, G. Dallner, P. Sindelar
- Biology, ChemistryJournal of neuropathology and experimental…
- 1 July 1999
Both the vinyl ether bond of phosphatidylethanolamine plasmalogen and polyunsaturated fatty acids are major targets in oxidative stress; thus, these specific lipid modifications strongly support the involvement of free radicals in the pathogenesis of AD.
Fatty acid composition of brain phospholipids in aging and in Alzheimer’s disease
The findings do not support the hypothesis that AD reflects an accelerated aging process, and changes in saturated/polyunsaturated FA ratio are likely to influence cellular function, which in turn may cause certain neural deficiencies.
The antioxidant role of coenzyme Q.
Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency
Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins.