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Cloning and Characterization of the Human Activity-dependent Neuroprotective Protein*
We have recently cloned the mouse activity-dependent neuroprotective protein (ADNP). Here, we disclose the cloning of human ADNP (hADNP) from a fetal brain cDNA library. Comparative sequence analysisExpand
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Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide
The clinical manifestations of AIDS (acquired immune deficiency syndrome) often include neuropsychiatric and neurological deficits1–4, including early memory loss and progressive dementia. HIV (humanExpand
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A femtomolar-acting neuroprotective peptide.
A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting neuroprotection at unprecedented concentrations, is revealed. This peptide prevented neuronal cell death associated withExpand
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Complete Sequence of a Novel Protein Containing a Femtomolar‐Activity‐Dependent Neuroprotective Peptide
Abstract : The vulnerability of neurons and the irreversibility of loss make discoveries of neuroprotective compounds fundamentally important. Here, the complete coding sequence of a novel proteinExpand
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Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome.
Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in aExpand
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Activity-dependent neurotrophic factor: structure-activity relationships of femtomolar-acting peptides.
Activity-dependent neurotrophic factor (ADNF) is a glia-derived protein that is neuroprotective at femtomolar concentrations. A 14-amino acid peptide of ADNF (ADNF-14) has been reported that protectsExpand
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PACAP Functions as a Neurotrophic Factor a
In addition to classical neurotrophic factors, neurotransmitters and neuropeptides also exhibit neurotrophic activities.' The central nervous system (CNS) contains a variety of neuropeptides inExpand
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Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Tumor Necrosis Factor α Transcriptional Activation by Regulating Nuclear Factor-kB and cAMP Response
Tumor necrosis factor α (TNFα), an early cytokine produced by activated macrophages, plays an essential role in normal and pathological inflammatory reactions. The excessive production of TNFα isExpand
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Activity-dependent neuroprotective protein: a novel gene essential for brain formation.
We have recently cloned the novel homeobox-containing activity-dependent neuroprotective protein (ADNP). In the current study, mouse ADNP was shown to be expressed at the time of neural tube closure,Expand
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A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice.
Brain injury induces disruption of the blood-brain barrier, edema, and release of autodestructive factors that produce delayed neuronal damage. NAPSVIPQ (NAP), a femtomolar-acting peptide, is shownExpand
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