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Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide
It is suggested that the neuronal deficits associated with HIV may not be entirely a result of infectivity, but that gp120 shed from HIV could directly produce the neuropathology as a consequence of its interference with endogenous neurotrophic substances.
A femtomolar-acting neuroprotective peptide.
These studies identify a potent neuroprotective glial protein and an active peptide that provide a basis for developing treatments of currently intractable neurodegenerative diseases.
Complete Sequence of a Novel Protein Containing a Femtomolar‐Activity‐Dependent Neuroprotective Peptide
The relative enrichment of the novel mRNA transcripts in the brain and the increases found in the presence of vasoactive intestinal peptide, an established neuroprotective substance, imply a role for the cloned protein in neuronal function.
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome.
- C. Spong, D. Abebe, I. Gozes, D. Brenneman, J. Hill
- MedicineThe Journal of pharmacology and experimental…
- 1 May 2001
It is demonstrated that fetal death and growth restriction associated with prenatal alcohol exposure were prevented by combinatorial peptide treatment and it is suggested that this therapeutic strategy be explored in other models/diseases associated with oxidative stress.
Activity-dependent neurotrophic factor: structure-activity relationships of femtomolar-acting peptides.
- D. Brenneman, J. Hauser, I. Gozes
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 May 1998
ADNF-9, like ADNF-14, was neuroprotective against N-methyl-D-aspartate and the beta-amyloid peptide (amino acids 25-35), and had a much broader range of effective concentrations than AD NF-14.
PACAP Functions as a Neurotrophic Factor a
- A. Arimura, A. Somogyvari, D. Brenneman
- BiologyAnnals of the New York Academy of Sciences
- 1 October 1994
Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from ovine hypothalamic tissues during an attempt to isolate a novel hypophysiotropic hormone based on the ability to activate adenYLate Cyclase in rat pituitary cell cultures.
Cloning and Characterization of the Human Activity-dependent Neuroprotective Protein*
Down-regulation of ADNP by antisense oligodeoxynucleotides up-regulated the tumor suppressor p53 and reduced the viability of intestinal cancer cells by 90%.
Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Tumor Necrosis Factor α Transcriptional Activation by Regulating Nuclear Factor-kB and cAMP Response…
Because TNFα plays a central role in various inflammatory diseases such as endotoxic shock, multiple sclerosis, cerebral malaria, and various autoimmune conditions, the down-regulatory effect of VIP/PACAP may have a significant therapeutic potential.
Activity-dependent neuroprotective protein: a novel gene essential for brain formation.
Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease 1 This manuscript is based on a poster presented at the Brain…