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Metyrosine

Known as: (-)-alpha-Methyl-L-tyrosine, Metirosinum, (S)-alpha-Methyltyrosine 
A methylated tyrosine, a catecholamine synthesis antagonist with antihypertensive property. Metyrosine competitively inhibits tyrosine 3… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (6)

Adrenergic AntagonistsAntihypertensive AgentsMethyltyrosinesTyrosine
Catecholamine Synthesis Inhibitors [MoA]HypersensitivityPheochromocytomacarbidopa/iodine I 131 metaiodobenzylguanidine/isotretinoin/methylprednisolone/metyrosine

Papers overview

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Highly Cited
2009
Highly Cited
2009
Design and synthesis of potent in vivo antagonists of oxytocin.
We have previously shown that the substitution of 8-ornithine and 2-O-methyltyrosine alone and in combination in [1… 
Highly Cited
1990
Highly Cited
1990
Permanent release of noradrenaline modulates respiratory frequency in the newborn rat: an in vitro study.
1. Respiratory activity was recorded on ventral cervical roots during in vitro experiments performed on superfused newborn rat… 
Highly Cited
1987
Highly Cited
1987
Oxytocin predominantly excites putative oxytocin neurons in the rat supraoptic nucleus in vitro
Highly Cited
1986
Highly Cited
1986
Synthetic antagonists of the myometrial response to vasopressin and oxytocin.
With the aim of developing inhibitors of vasopressin- and oxytocin-induced uterine activity, 17 analogues of 1-deamino-oxytocin… 
Highly Cited
1986
Highly Cited
1986
Characteristics of the Large Neutral Amino Acid Transport System of Bovine Brain Microvessel Endothelial Cell Monolayers
Abstract: The large neutral amino acid (LNAA) transport system, or L (leucine) system, in primary cultures of bovine brain… 
Highly Cited
1985
Highly Cited
1985
Acute restraint stress decreases dopamine synthesis and turnover in the median eminence: a model for the study of the inhibitory neuronal influences on tuberoinfundibular dopaminergic neurons.
The effects of acute stress on serum prolactin concentrations and tuberoinfundibular dopaminergic (TIDA) neuronal activity were… 
Highly Cited
1982
Highly Cited
1982
Further studies on the long-term depletion of striatal dopamine in iprindole-treated rats by amphetamine
Highly Cited
1976
Highly Cited
1976
Selective actions of prolactin on catecholamine turnover in the hypothalamus and on serum LH and FSH.
The effects of prolactin (PRL) administration on catecholamine turnover in various brain regions of ovariectomized rats were… 
Highly Cited
1975
Highly Cited
1975
Catecholaminergic mechanisms of the lateral hypothalamus: Their role in the mediation of amphetamine anorexia
Highly Cited
1972
Highly Cited
1972
Fluorometric estimation of 4‐hydroxy‐3‐methoxyphenylethyleneglycol sulphate in brain
1 A simple, sensitive, and selective method was developed for the fluorimetric estimation of 4‐hydroxy‐3… 
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