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Vasopressin/Serotonin Interactions in the Anterior Hypothalamus Control Aggressive Behavior in Golden Hamsters
The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters to suggest that5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system. Expand
Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis.
The physiological role of the serotonin transporter on serotonin neuronal membranes apparently is to inactivate serotonin that has been released into the synaptic cleft, and serotonin neurons decrease their firing and release of serotonin to limit the magnitude of the increase in extracellular serotonin concentration. Expand
Supersensitization of the oral response to SKF 38393 in neonatal 6-OHDA-lesioned rats is mediated through a serotonin system.
The mixed 5- HT1C and 5-HT2 receptor agonist, m-chlorophenylpiperazine (m-CPP), produced a slight increase in oral activity in control rats and a marked increase in Oral activity in 6-OHDA-lesioned rats. Expand
Serotonin receptors involved in regulation of pituitary-adrenocortical function in rats
  • R. Fuller
  • Medicine, Biology
  • Behavioural Brain Research
  • 15 December 1995
Serotonergic activation can also increase plasma levels of ACTH and cortisol in humans, and although the effects in humans are less well characterized than in rats, they seem to be useful as a way of probing brain serotonergic function in disease or after drug treatment. Expand
Dopamine deficiency in the weaver mutant mouse
It is illustrated that weaver mice have specific deficiencies in the dopamine system and might provide a way of examining the biochemical and behavioral effects of long term dopamine deficiency and a way to examine drugs to treat dopamine-deficient states in vivo. Expand
Fluoxetine, a selective inhibitor of serotonin uptake
It is apparent that fluoxetine has found a useful niche in therapy, and can be used as a probe to determine the role of serotonin in modulating human pathophysiologies. Expand
Serotonin Uptake and Serotonin Uptake Inhibition
  • R. Fuller, D. Wong
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1 October 1990
Some serotonin uptake inhibitors are finding therapeutic uses in mental depression and other psychiatric disorders and in treating obesity and bulimia; other therapeutic applications continue to be evaluated. Expand
Isolation and structure/activity features of halomon-related antitumor monoterpenes from the red alga Portieria hornemannii.
Ten halogenated monoterpenes related to the novel antitumor compound halomon or to the carbocyclic analog 7 have been isolated from different geographic collections of the red alga, Portieria hornemannii, providing some interesting initial insights into the structure/activity relationships in this series. Expand
Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum.
The increased extracellular concentration of serotonin no doubt resulted from inhibition of the serotonin uptake carrier by fluoxetine, and the lack of change in dopamine is evidence for the specificity of action of this uptake inhibitor. Expand
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
Non-competitive NMDA antagonists, like MK801, may not be useful to alleviate opiate withdrawal symptoms in man because of their PCP-like side effects, however, competitive NMDAagonists, like LY274614, could be of great benefit for alleviating opiates withdrawal Symptoms in man. Expand