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Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines.
A method of measuring the rate of synthesis of catecholamines in various tissues takes advantage of the steady state relationship in which the rate of catecholamine formation is equal to the rate ofExpand
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Nicotine abstinence in the mouse
We present evidence that intermittent administration of nicotine, 2 mg/kg s.c., four times daily to mice for 14 days produces a somatic abstinence syndrome after discontinuing treatment. The nicotineExpand
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Protein kinase C activators decrease dopamine uptake into striatal synaptosomes.
Incubation with either of the protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and sn-1,2 dioctanoylglycerol (DiC8) decreased the uptake of dopamine into striatal synaptosomes,Expand
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Beta-phenylethylamine: a specific substrate for type B monoamine oxidase of brain.
  • H. Y. Yang, N. Neff
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 November 1973
β-Phenylethylamine and serotonin were oxidatively deaminated by separate forms of monoamine oxidase of rat brain wimen studied in vitro . These forms, designated as type A and type B enzyme, haveExpand
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The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines.
  • H. Y. Yang, N. Neff
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 June 1974
Two types of monoamine oxidase were identified in vivo in rat brain. These enzymes, designated as type A and type B, were inhibited differentially by the drugs clorgyline (inhibitor of type A enzyme)Expand
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Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys
Scimmie scoiattolo trattate cronicamente con MnO2 presentano disturbi del sistema extrapiramidale ed una riduzione delle concentrazioni di serotonina e dopamina nel nucleo caudato. L'intensità deiExpand
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GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain.
We investigated the ability of GM1 to induce phosphorylation of the tyrosine kinase receptor for neurotrophins, Trk, in rat brain, and activation of possible down-stream signaling cascades. GM1Expand
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Aromatic L-amino acid decarboxylase activity of mouse striatum is modulated via dopamine receptors.
Aromatic L-amino acid decarboxylase (AAAD) activity is enhanced in the striatum of control and MPTP-treated mice after administration of a single dose of the dopamine receptor antagonistsExpand
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Nicotine and endogenous opioids: Neurochemical and pharmacological evidence
Although the mesolimbic dopamine hypothesis is the most influential theory of nicotine reward and reinforcement, there has been a consensus that other neurotransmitter systems contribute to theExpand
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Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy
During pregnancy, the uterus undergoes a profound sympathetic denervation. To explore whether this is associated with changes in neurotrophic factors, we assayed nerve growth factor (NGF) and NGFExpand
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