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Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity
TLDR
The possibility that a fat-rich diet during pregnancy alters the development of hypothalamic peptide systems in utero, producing neuronal changes in the offspring that persist postnatally in the absence of the diet and have long-term consequences is examined. Expand
Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
TLDR
These findings, demonstrating that exogenous NPY is capable of overriding mechanisms of satiety and body weight control, suggest that disturbances in NPY function may play a role in some disorders of eating behavior and body Weight regulation. Expand
Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus.
TLDR
An important role is suggested for hypothalamic NPY, or a structurally-related peptide, in the regulation of feeding and drinking behavior in satiated, brain-cannulated rats. Expand
Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.
TLDR
The powerful stimulation of feeding elicited by this neuropeptide suggests an important role for hypothalamic NPY, or a structurally related peptide, in the regulation of feeding behavior. Expand
Opiate-like effects of sugar on gene expression in reward areas of the rat brain.
TLDR
A major role for the nucleus accumbens in mediating the effects of naturally rewarding substances is supported and an animal model for studying the common substrates of drug addiction and eating disorders is extended. Expand
Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion
TLDR
Results suggest that hypothalamic receptors sensitive to PYY and NPY may participate in the control of carbohydrate consumption, with little or no effect on protein or fat consumption. Expand
The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)
TLDR
Behavioral results show that the perifornical hypothalamus (PFH), at the level of the caudal paraventricular nucleus, is the most sensitive hypothalamic site for NPY-induced eating, and suggest both that the PFH may be the primary hypothalamus site containing feeding-related NPy-sensitive receptors and that other sites distributed within the hypothalamus also can mediate NPY's effects. Expand
Hypothalamic serotonin in control of eating behavior, meal size, and body weight
TLDR
Evidence that supports a role for hypothalamic serotonergic receptor mechanisms in the mediation of eating behavior and body weight disorders is reviewed, and a model that proposes the involvement of circulating hormones and glucose in this feedback process is described. Expand
Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status
TLDR
Support is provided for the idea that the variations of hypothalamic NPY after food deprivation reflect a specific physiological response of feeding regulatory system to alterations in the animal nutritional state and body weight. Expand
Hypothalamic control of energy balance: different peptides, different functions
TLDR
Nine peptides in the hypothalamus that have emerged as key players in the process of energy homeostasis are summarized in an attempt to formulate a clear statement on the underlying function of each of these peptides and also on how they work together to create and maintain energyHomeostasis. Expand
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