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Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
We report the molecular cloning and characterization of two structurally related putative receptor tyrosine kinases, encoded by distinct genes (tie-1 and tie-2) on mouse chromosome 4. Both tie-1 andExpand
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Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism.
Multiple cell types contribute to the pulmonary barrier including Type I and Type II alveolar epithelium. The objective of this research was to establish and characterize an in vitro model of Type IIExpand
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Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier.
A relatively simple, widely applicable, and robust in vitro method of predicting blood-brain barrier (BBB) permeability to central nervous system-acting drugs is an increasing need. A cell-basedExpand
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Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers.
When using cultured cell monolayers to determine the mechanism of transcellular diffusion of molecules, it may be important to identify the fraction that moves through the paracellular route orExpand
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Bovine Brain Microvessel Endothelial Cell Monolayers as a Model System for the Blood‐Brain Barrier a
Investigation of blood-brain barrier permeability and metabolic processes, and their regulation by endogenous or exogenous factors, will be important for development of efficient and selectiveExpand
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Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration.
Rat primary hepatocytes were cultured under different extracellular matrix configurations and evaluated for the acquisition and maintenance of structural and functional cell polarity. De novoExpand
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Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery.
The objective of this research was to examine the human sub-bronchial gland cell line, Calu-3, and assess its potential as a metabolic and transport model to study drug delivery to the respiratoryExpand
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Permeability properties of monolayers of the human trophoblast cell line BeWo.
The BeWo cell line (b30 clone) has been examined as a potential in vitro system to study transplacental transport. At the light and electron microscope level, the cells were observed to formExpand
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Efflux transporters of the human placenta.
The use of pharmaceuticals during pregnancy is often a necessity for the health of the mother. Until recently, the placenta was viewed as a passive organ through which molecules are passedExpand
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