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Mecp2 Deficiency Disrupts Norepinephrine and Respiratory Systems in Mice
Rett syndrome is a severe X-linked neurological disorder in which most patients have mutations in the methyl-CpG binding protein 2 (MECP2) gene and suffer from bioaminergic deficiencies andExpand
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MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth
The genetic basis for the development of brainstem neurons that generate respiratory rhythm is unknown. Here we show that mice deficient for the transcription factor MafB die from central apnea atExpand
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Perinatal maturation of the mouse respiratory rhythm‐generator: in vivo and in vitro studies
In vivo (plethysmography) and in vitro (en bloc preparations) experiments were performed from embryonic day 16 (E16) to postnatal day 9 (P9) in order to analyse the perinatal maturation of theExpand
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Modulation of the respiratory rhythm generator by the pontine noradrenergic A5 and A6 groups in rodents
The aim of the present review is to summarise available studies dealing with the respiratory control exerted by pontine noradrenergic neurones in neonatal and adult mammals. During the perinatalExpand
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Acetylcholine and central chemosensitivity: in vitro study in the newborn rat.
In vitro experiments were performed in the superfused brainstem-spinal cord preparation of newborn rats in order to analyse the central respiratory effects of acetylcholine. The central motor outputExpand
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Phox2a Gene, A6 Neurons, and Noradrenaline Are Essential for Development of Normal Respiratory Rhythm in Mice
Although respiration is vital to the survival of all mammals from the moment of birth, little is known about the genetic factors controlling the prenatal maturation of this physiological process.Expand
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Necdin Plays a Role in the Serotonergic Modulation of the Mouse Respiratory Network: Implication for Prader-Willi Syndrome
Prader-Willi syndrome is a neurogenetic disease resulting from the absence of paternal expression of several imprinted genes, including NECDIN. Prader-Willi children and adults have severe breathingExpand
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Maturation of the mammalian respiratory system.
In this review, the maturational changes occurring in the mammalian respiratory network from fetal to adult ages are analyzed. Most of the data presented were obtained on rodents using in vitroExpand
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Noradrenergic modulation of the medullary respiratory rhythm generator in the newborn rat: an in vitro study.
1. Superfused brain stem‐spinal cord preparations of newborn rats, which continue to show a rhythmic respiratory activity in vitro, were used to analyse the mechanisms whereby the A5 noradrenergicExpand
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Compared effects of serotonin on cervical and hypoglossal inspiratory activities: an in vitro study in the newborn rat.
1. Experiments were performed on the brain stem‐spinal cord preparation of newborn rats, in which the phrenic and hypoglossal nerves continue to show rhythmic respiratory activity in vitro, in orderExpand
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