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LY 379268

Known as: LY-379268, LY379268 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Amino AcidsBridged Bicyclo Compounds, Heterocyclic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity
RationaleGroup II metabotropic glutamate receptors (mGluRs) comprise the mGluR2 and mGluR3 subtypes, the activation and… 
Highly Cited
2007
Highly Cited
2007
Systemic and Central Amygdala Injections of the mGluR2/3 Agonist LY379268 Attenuate the Expression of Incubation of Cocaine Craving
Highly Cited
2007
Highly Cited
2007
Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence
The motivation to maintain nicotine self-administration and dependence may involve alterations in glutamatergic neurotransmission… 
Highly Cited
2007
Highly Cited
2007
The Use of Knock-Out Mice Unravels Distinct Roles for mGlu2 and mGlu3 Metabotropic Glutamate Receptors in Mechanisms of Neurodegeneration/Neuroprotection
Dual metabotropic glutamate 2/3 (mGlu2/3) receptor agonists have been examined with success in the clinic with positive proof of… 
Highly Cited
2006
Highly Cited
2006
Activation of Group II Metabotropic Glutamate Receptors Attenuates Both Stress and Cue-Induced Ethanol-Seeking and Modulates c-fos Expression in the Hippocampus and Amygdala
Major precipitating factors for relapse to drug use are stress and exposure to drug-related environmental stimuli. Group II… 
Highly Cited
2006
Highly Cited
2006
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats
RationaleGroup II metabotropic glutamate receptor (mGluR2/3) agonists are proposed to serve as potential treatment for addiction… 
Review
2003
Review
2003
Glutamate metabotropic receptors as targets for drug therapy in epilepsy.
Review
2001
Review
2001
Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs
Metabotropic glutamate (mGlu) receptors have been considered as potential targets for neuroprotective drugs, but the lack of… 
Highly Cited
2000
Highly Cited
2000
The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing.
Highly Cited
1999
Highly Cited
1999
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two…
As part of our ongoing research program aimed at the identification of highly potent, selective, and systemically active agonists… 
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