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Psychological and Cardiovascular Effects and Short-Term Sequelae of MDMA (“Ecstasy”) in MDMA-Naïve Healthy Volunteers
The present findings are consistent with the hypothesis that MDMA produces a different psychological profile than classic hallucinogens or psychostimulants. Expand
Gender differences in the subjective effects of MDMA
The fact that equal doses of MDMA per kilogram body weight produce stronger responses in women compared to men is consistent with an increased susceptibility of women to the 5-HT-releasing effects of MDMA. Expand
To Dope or Not to Dope: Neuroenhancement with Prescription Drugs and Drugs of Abuse among Swiss University Students
A significant proportion of Swiss university students across most academic disciplines reported neuroenhancement with prescription drugs and drugs of abuse, however, these substances are rarely used on a daily basis and more sporadically used prior to exams. Expand
Monoamine transporter and receptor interaction profiles of a new series of designer cathinones
Psychoactive β-keto amphetamines (cathinones) are sold as "bath salts" or "legal highs" and recreationally abused. We characterized the pharmacology of a new series of cathinones, includingExpand
Acute Psychological Effects of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) are Attenuated by the Serotonin Uptake Inhibitor Citalopram
The finding that citalopram pretreatment in a double-blind placebo-controlled psychometric study in 16 healthy human volunteers produced an emotional state with heightened mood, increased self-confidence and extroversion, moderate derealization, and an intensification of sensory perception suggests that the psychological effects of MDMA are mediated via action at the5-HT uptake site to increase 5-HT release through the carrier, as expected from animal studies. Expand
Psychological and Physiological Effects of MDMA (“Ecstasy”) after Pretreatment with the 5-HT2 Antagonist Ketanserin in Healthy Humans
Ketanserin attenuated MDMA-induced perceptual changes, emotional excitation, and acute adverse responses but had little effect on MDMA- induced positive mood, well-being, extroversion, and short-term sequelae, suggesting a contributing role for 5-HT2 receptors in the action of MDMA in humans. Expand
Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence
Findings indicate an important role for mGlu2/3 receptors in the posterior VTA and the NAc shell in the mediation of the rewarding effects of nicotine and potentially in cue-induced nicotine-seeking behavior. Expand
MDMA enhances emotional empathy and prosocial behavior.
MDMA sex-specifically altered the recognition of emotions, emotional empathy and prosociality and may be useful when MDMA is administered in conjunction with psychotherapy in patients with social dysfunction or post-traumatic stress disorder. Expand
Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling.
  • M. Liechti
  • Medicine
  • Swiss medical weekly
  • 14 January 2015
The relative serotonergic vs dopaminergic activity can be helpful to predict the desired psychotropic but also the toxic effects of novel substances as well as their potential for addiction. Expand
The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3, 4-methylenedioxymethamphetamine (‘Ecstasy’) in healthy volunteers
It is suggested that physiological effects of MDMA in humans are partially due to an interaction of MDMA with the serotonin carrier and a subsequent release of serotonin. Expand