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Bridged Bicyclo Compounds, Heterocyclic

Known as: Heterocyclic Bicyclo Compounds, Bicyclo Compounds, Heterocyclic, Heterocyclic Compounds, Bicyclic 
Heterocyclic compounds that contain two rings that share two non-adjacent atoms in common.
National Institutes of Health

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BMS 641988BPR1K653CD 222CHIBA 1001
antagonists & inhibitorschemical synthesis

Papers overview

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Review
2011
Review
2011
Asymmetric N-Heterocyclic Carbene (NHC) Catalyzed Acyl Anion Reactivity.
The generation of acyl anion equivalents has been of interest to the synthetic community since the early 1960’s. Of the numerous… 
Highly Cited
2006
Highly Cited
2006
Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.
N-Heterocyclic carbenes were found to be highly effective organocatalysts in activating TMSCN for facile cyanosilylation of… 
Highly Cited
2006
Highly Cited
2006
Heterocyclic quinol-type fluorophores: synthesis, X-ray crystal structures, and solid-state photophysical properties of novel 5-hydroxy-5-substituent-benzo[b]naphtho[1,2-d]furan-6-one and 3-hydroxy-3…
Novel heterocyclic quinol-type fluorophores (4 a-c) and (5 a-c) that contain substituents (R = Me, Bu, Ph) with nonconjugated… 
Highly Cited
2005
Highly Cited
2005
Highly efficient access to strained bicyclic ketals via gold-catalyzed cycloisomerization of bis-homopropargylic diols.
A highly efficient gold-catalyzed cycloisomerization reaction of bis-homopropargylic diols is described. The cyclizations are… 
Highly Cited
2004
Highly Cited
2004
Rhodium(II)-catalyzed aziridination of allyl-substituted sulfonamides and carbamates.
Several unsaturated sulfonamides underwent intramolecular aziridination when treated with PhI(OAc)(2), MgO, and catalytic Rh(2… 
Highly Cited
2003
Highly Cited
2003
Synthesis, structural characterization and in vitro cytotoxicity of organotin(IV) derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2…
Highly Cited
2003
Highly Cited
2003
An association between NQO1 genetic polymorphism and risk of bladder cancer.
Highly Cited
1997
Highly Cited
1997
Assessment of the human exposure to heterocyclic amines.
Heterocyclic amines are possible human carcinogens and fried meat is an important source of exposure in the Western diet. To… 
Highly Cited
1996
Highly Cited
1996
Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues.
One of the mutagenic and carcinogenic heterocyclic amines (HCAs), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), is… 
Highly Cited
1965
Highly Cited
1965
The Carcinostatic Activity of α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones
Isoquinoline-1-carboxaldehyde thiosemicarbazone (IQ-1) has been shown to have carcinostatic activity against leukemias L-1210 and… 
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