FAQ

Bridged Bicyclo Compounds, Heterocyclic

Known as: Heterocyclic Bicyclo Compounds, Bicyclo Compounds, Heterocyclic, Heterocyclic Compounds, Bicyclic 
Heterocyclic compounds that contain two rings that share two non-adjacent atoms in common.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1945-2018
05019452017

Related topics

Related topics

50 relations

Narrower (49)

1,4-C(2)-cyclam1,4-diethylepipolythiodioxopiperazine1-ethoxysilatrane2,3-dehydrobrevicomin
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antagonists & inhibitors

Related mentions per year

Related mentions per year

1945-2018
19401960198020002020
Bridged Bicyclo Compounds, Heterocyclic
tert-butylbicyclophosphorothionate
zacopride
renzapride
bicozamycin
silatrane

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Phage-encoded combinatorial chemical libraries based on bicyclic peptides.
Here we describe a phage strategy for the selection of ligands based on bicyclic or linear peptides attached covalently to an… (More)
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Highly Cited
2008
Highly Cited
2008
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require… (More)
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Highly Cited
2006
Highly Cited
2006
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.
PA-824 is a promising new compound for the treatment of tuberculosis that is currently undergoing human trials. Like its… (More)
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Highly Cited
2006
Highly Cited
2006
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
A chemical synthesis platform with broad applications and flexibility was rationally designed to inhibit biogenesis of adhesive… (More)
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Highly Cited
2006
Highly Cited
2006
Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma.
We have recently shown that cannabinoids induce growth inhibition and apoptosis in mantle cell lymphoma (MCL), a malignant B-cell… (More)
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Highly Cited
2005
Highly Cited
2005
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity.
A series of new 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitrile derivatives that function as irreversible inhibitors of… (More)
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Highly Cited
2004
Highly Cited
2004
Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism.
Microglia, as phagocytes and antigen-presenting cells in the central nervous system, are activated in such disease processes as… (More)
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Highly Cited
1998
Highly Cited
1998
Heterocyclic amine content of pork products cooked by different methods and to varying degrees of doneness.
Heterocyclic amines (HCAs) are known mutagens and animal carcinogens produced in meats cooked at high temperature. As pork is the… (More)
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Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor…
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as… (More)
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Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination.
 
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