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Inhibition of lipopolysaccharide-stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway.
TLDR
The blockade of NO production by CYL-4d in LPS-stimulated RAW 264.7 cells is attributed mainly to interference in the MEK4-JNK-AP-1 signaling pathway and is not restricted to TLR4 activation and immortalized macrophage-like cells. Expand
Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.
TLDR
Findings suggest a mechanism of cytotoxic action of YC-1 and indicate that YC -1 may be a promising chemotherapy agent against lung cancer. Expand
The anti‐inflammatory carbazole, LCY‐2‐CHO, inhibits lipopolysaccharide‐induced inflammatory mediator expression through inhibition of the p38 mitogen‐activated protein kinase signaling pathway in
TLDR
LCY‐2‐CHO downregulates inflammatory iNOS, COX‐2, and TNF‐α gene expression in macrophages through interfering with p38 MAPK and AP‐1 activation, and was capable of interfering with post‐transcriptional regulation. Expand
(-)-Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathway.
TLDR
The results showed that EGCG induced growth inhibition in a dose- and time-dependent manner and exerted low cytotoxicity on Detroit 551 normal human embryonic skin cell, confirming that E GCG may be a drug candidate for the treatment of human adrenal cancer in the future. Expand
Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells.
TLDR
It is demonstrated for the first time that geraniin triggered cell death by caspase-3-mediated cleavage of FAK, which may provide a pivotal mechanism for its cancer-chemopreventive action. Expand
Neuroprotective Effects of Ugonin K on Hydrogen Peroxide-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells
TLDR
Results suggest that ugonin K by activation of ERK1/2 and PI3K/Akt signal pathways protects SH-SY5Y cells from H2O2-induced apoptosis. Expand
Acetogenin and prenylated flavonoids from Helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by neutrophils.
TLDR
Six known compounds and four new compounds, together with six known compounds, were isolated and purified from the rhizomes of Helminthostachys zeylanica by column chromatography and high performance liquid chromatography (HPLC) via bioactivity-guided fractionation isolation. Expand
BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide
TLDR
Anti-glioblastoma profiles of a series of synthetic carbazole derivatives were evaluated in vitro, providing molecular evidence for the mode of action governing the ability of BC3EE2,9B to sensitize drug-resistant glioblastomas cells to the chemotherapeutic agent TMZ. Expand
CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells.
TLDR
Results showed that CCT327 combined with TRAIL treatment may provide an effective therapeutic strategy for cancer. Expand
Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia.
TLDR
LCY-2-CHO inhibits NO production in microglia through the blockade of AP-1 and C/EBP activation and attenuated the phosphorylation of C/ EBPbeta at Ser105 and Thr235 residues, which occurred concomitantly with LCY- 2-CHO inhibition of C-Jun expression and phosphorylated. Expand
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