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Glutamate as a neurotransmitter in the brain: review of physiology and pathology.
- B. Meldrum
- Medicine, Biology
- The Journal of nutrition
- 1 April 2000
Glutamate is the principal excitatory neurotransmitter in brain. Our knowledge of the glutamatergic synapse has advanced enormously in the last 10 years, primarily through application of molecular… Expand
Excitatory amino acid neurotoxicity and neurodegenerative disease.
The progress over the last 30 years in defining the role of excitatory amino acids in normal physiological function and in the abnormal neuronal activity of epilepsy has been reviewed in earlier… Expand
Molecular targets for antiepileptic drug development
SummaryThis review considers how recent advances in the physiology of ion channels and other potential molecular targets, in conjunction with new information on the genetics of idiopathic epilepsies,… Expand
Cerebral blood flow and metabolic rate early and late in prolonged epileptic seizures induced in rats by bicuculline.
Cerebral blood flow (CBF) and cerebral metablic rate for oxygen (CMRO2) have been studied during sustained epileptic seizures induced by bicuculline (1-2 mg/kg, i.v.) in paralysed Wistar rats,… Expand
Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.
In rats ischemia of the forebrain induced by a 30-minute occlusion of the carotid artery, followed by 120 minutes of arterial reperfusion, produced ischemic lesions of selectively vulnerable… Expand
Na+ channels as targets for neuroprotective drugs.
Drugs that block voltage-dependent Na+ channels are well known as local anaesthetics, antiarrhythmics and anticonvulsants. Recent studies show that these compounds also provide a powerful mechanism… Expand
Update on the Mechanism of Action of Antiepileptic Drugs
- B. Meldrum
- Chemistry, Medicine
- 1 December 1996
Summary: Novel antiepileptic drugs (AEDs) are thought to act on voltage‐sensitive ion channels, on inhibitory neurotransmission or on excitatory neurotransmission. Two successful examples of rational… Expand
Focal contralateral myoclonus produced by inhibition of GABA action in the caudate nucleus of rats.
Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives.
- B. Meldrum
- Biology, Medicine
- Progress in brain research
Selective neuronal loss following status epilepticus was first described just under 100 years ago. The acute pathology following status epilepticus was shown to be 'ischemic cell change' and was… Expand
Physiology of status epilepticus in primates.
In adolescent baboons the intravenous injection of bicuculline induced generalized seizures lasting up to five hours, which sometimes led to brain damage or death. Marked initial rises in arterial… Expand