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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.
TLDR
Continuous low-level exposure of mice to MPTP causes a Parkinson-like syndrome in an alpha-synuclein-dependent manner, and the inhibition of the ubiquitinproteasome system and the production of inclusion bodies were reduced.
Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain
TLDR
It is concluded that induction of DKK1 contributes to the pathological cascade triggered by β-amyloid and is critically involved in the process of tau phosphorylation.
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
TLDR
This review will evaluate more recently described potential uses of MEK, PI3K, Akt and mTOR inhibitors in the proliferation of malignant cells, suppression of CICs, cellular senescence and prevention of aging.
GSK-3 as potential target for therapeutic intervention in cancer
TLDR
This review will focus on the diverse roles that GSK-3 plays in various human cancers, in particular in solid tumors, and how this pivotal kinase interacts with multiple signaling pathways.
Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats
TLDR
A pronounced gender difference in the effects of PRS on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors is uncovered, suggesting that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females.
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
TLDR
The functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli are discussed and the recently described roles of these pathways in cancer stem cells, cellular senescence and aging are evaluated.
Metabotropic glutamate receptors in the basal ganglia motor circuit
TLDR
New understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders.
Vitamin D3: a helpful immuno‐modulator
TLDR
This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune‐regulatory effects of vitamin D3 on immune cells.
ISO-1 Binding to the Tautomerase Active Site of MIF Inhibits Its Pro-inflammatory Activity and Increases Survival in Severe Sepsis*
TLDR
The results identify ISO-1 as the first small molecule inhibitor of MIF proinflammatory activities with therapeutic implications and indicate the potential of the MIF active site as a novel target for therapeutic interventions in human sepsis.
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