D. Schoepp

Publications257
h-index71
Citations20,478
Highly Influential Citations1,072
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Pharmacological agents acting at subtypes of metabotropic glutamate receptors
View on Elsevier
Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors
TLDR
The neurochemical evidence for mGlu receptor‐mediated regulation of neurotransmitters, such as excitatory and inhibitory amino acids, monoamines, and neuropeptides is addressed.
View on Wiley
LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors
View on Elsevier
Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.
  • D. Schoepp
  • Biology
    The Journal of pharmacology and experimental…
  • 1 October 2001
TLDR
Gi-coupled mGlu receptors also may exist on presynaptic elements of neighboring gamma-aminobutyric acid neurons where they play a role in heterosynaptic suppressions of GABA release, suggesting that these receptors may have evolved to monitor glutamate that has "spilled out of the synapse".
View on PubMed
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
TLDR
These studies indicate that metabotropic glutamate receptors are interesting new targets to treat anxiety disorders in humans.
View on Springer
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
TLDR
The data suggest that mGlu2/3 receptor agonists have antipsychotic properties and may provide a new alternative for the treatment of schizophrenia.
View on Nature
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission
TLDR
The effects of a potent and selective agonist and a selective antagonist are used to show that kainate receptors, comprised of or containing GluR5 subunits, regulate synaptic inhibition in the hippocampus, an action that could contribute to the epileptogenic effects of kainates.
View on Nature
Metabotropic glutamate receptors: From the workbench to the bedside
View on Elsevier
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
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Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
TLDR
It is demonstrated that Abeta levels in the brain interstitial fluid are dynamically and directly influenced by synaptic activity on a timescale of minutes to hours, suggesting that synaptic activity may modulate a neurodegenerative disease process, in this case by influencing Abeta metabolism and ultimately region-specific Abeta deposition.
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