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Pharmacological agents acting at subtypes of metabotropic glutamate receptors
Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a recognized, but still relatively new area of excitatory amino acid research. Current understanding of the roles andExpand
Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors
Abstract: The G protein‐coupled metabotropic glutamate (mGlu) receptors are differentially localized at various synapses throughout the brain. Depending on the receptor subtype, they appear to beExpand
LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors
The in vitro pharmacology of a structurally novel compound, LY341495, was investigated at human recombinant metabotropic glutamate (mGlu) receptor subtypes expressed in non-neuronal (RGT, ratExpand
Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.
  • D. Schoepp
  • Biology, Medicine
  • The Journal of pharmacology and experimental…
  • 1 October 2001
Metabotropic glutamate (mGlu) receptors, which include mGlu1-8 receptors, are a heterogeneous family of G-protein-coupled receptors which function to modulate brain excitability via presynaptic,Expand
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and current treatments are less than satisfactory. So, the discovery of novel approaches to treat anxietyExpand
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within limbic structures of the brain. TheseExpand
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission
The principal excitatory neurotransmitter in the vertebrate central nervous system, L-glutamate, acts on three classes of ionotripic glutamate receptors, named after the agonists AMPAExpand
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
Aggregation of the amyloid-beta (Abeta) peptide in the extracellular space of the brain is central to Alzheimer's disease pathogenesis. Abeta aggregation is concentration dependent and brain regionExpand
The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.
Previous animal studies have indicated that drugs targeted at metabotropic glutamate (mGlu) receptors may be useful for treatment of psychosis. In this article, the effects of the novel, potent, andExpand
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Summary Aggregation of the amyloid-β (Aβ) peptide in the extracellular space of the brain is central to Alzheimer's disease pathogenesis. Aβ aggregation is concentration dependent and brain regionExpand