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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.
TLDR
Continuous low-level exposure of mice to MPTP causes a Parkinson-like syndrome in an alpha-synuclein-dependent manner, and the inhibition of the ubiquitinproteasome system and the production of inclusion bodies were reduced.
Endocytosis at the nanoscale.
TLDR
An overview of the biology of endocytosis is presented and its implications in cell internalisation of nanoparticles are discussed, including how nanoparticle size, shape and surface chemistry can control this process effectively.
Metabotropic glutamate receptors in the basal ganglia motor circuit
TLDR
New understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders.
Neuroprotection by Glial Metabotropic Glutamate Receptors Is Mediated by Transforming Growth Factor-β
TLDR
It is concluded that a transient activation of group-II mGlu receptors (presumably mGLU3 receptors) in astrocytes leads to an increased formation and release of TGFβ, which in turn protects neighbor neurons against excitotoxic death.
L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors
TLDR
The rapid and long-lasting antidepressant action of LAC strongly suggests a unique approach to examine the epigenetic hypothesis of depressive disorders in humans, paving the way for more efficient antidepressants with faster onset of action.
Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation
TLDR
The high amounts of glutamate in neuroinflammation might reflect a counterregulatory mechanism that is protective in nature and might be harnessed therapeutically for restricting immunopathology in multiple sclerosis.
Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells
TLDR
A novel function of mGlu receptors is disclosed and new potential strategies for the optimization of cell replacement therapy in neurodegenerative disorders are offered.
Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs
TLDR
A series of observations suggest a potential application of mGlu5 receptor antagonists in chronic neurodegenerative disorders, such as amyotrophic lateral sclerosis and Alzheimer disease.
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions.
TLDR
The results show that synucleins are not essential components of the basic machinery for neurotransmitter release but may contribute to the long-term regulation and/or maintenance of presynaptic function.
Selective Blockade of Type-1 Metabotropic Glutamate Receptors Induces Neuroprotection by Enhancing Gabaergic Transmission
TLDR
Results indicate that selective blockade of mGlu1 receptors produces neuroprotection by enhancing inhibitory postsynaptic currents in GABAergic transmission.
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