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LDLR gene

Known as: LDLR, familial hypercholesterolemia, LDLCQ2 
This gene plays a role in the modulation of ligand-specific receptor-mediated endocytosis, and also plays a regulatory role in cholesterol synthesis.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The proprotein convertase subtilisin/kexin-type 9 (PCSK9), which promotes degradation of the hepatic low density lipoprotein… 
Review
2004
Review
2004
The clinical phenotype of heterozygous familial hypercholesterolemia (FH) is characterized by increased plasma levels of total… 
Review
2004
Review
2004
Familial hypercholesterolemia (FH) is an autosomal disorder characterized by increased levels of total cholesterol and low… 
Highly Cited
2002
Highly Cited
2002
To perform vectorial secretory and transport functions that are critical for the survival of the organism, epithelial cells sort… 
Highly Cited
2001
Highly Cited
2001
Leptin-deficient mice (ob/ob) are an excellent murine model for obesity, insulin resistance, and diabetes, all of which are… 
Highly Cited
2000
Highly Cited
2000
The role of macrophage lipoprotein lipase (LPL) expression in atherosclerotic lesion formation was examined in low density… 
Highly Cited
1996
Highly Cited
1996
Lipoprotein lipase (LPL) is a key enzyme in the hydrolysis of triglyceride-rich lipoproteins. Conflicting results have been… 
Highly Cited
1993
Highly Cited
1993
  • J. HerzR. Gerard
  • Proceedings of the National Academy of Sciences…
  • 1993
  • Corpus ID: 19837199
We have explored the use of adenovirus-mediated gene transfer to transiently elicit production of low density lipoprotein (LDL…