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LDLR gene

Known as: LDLR, familial hypercholesterolemia, LDLCQ2 
This gene plays a role in the modulation of ligand-specific receptor-mediated endocytosis, and also plays a regulatory role in cholesterol synthesis.
National Institutes of Health

Related topics

Related topics

9 relations
Cholesterol HomeostasisHypercholesterolemia, FamilialHyperlipoproteinemia Type IIaLDLR protein, human

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LDLR wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress
Highly Cited
2008
Highly Cited
2008
Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels*
The proprotein convertase subtilisin/kexin-type 9 (PCSK9), which promotes degradation of the hepatic low density lipoprotein… 
Highly Cited
2001
Highly Cited
2001
Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor*
Leptin-deficient mice (ob/ob) are an excellent murine model for obesity, insulin resistance, and diabetes, all of which are… 
Highly Cited
2000
Highly Cited
2000
Macrophage Lipoprotein Lipase Promotes Foam Cell Formation and Atherosclerosis in Low Density Lipoprotein Receptor-deficient Mice*
The role of macrophage lipoprotein lipase (LPL) expression in atherosclerotic lesion formation was examined in low density… 
Highly Cited
1996
Highly Cited
1996
Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.
Lipoprotein lipase (LPL) is a key enzyme in the hydrolysis of triglyceride-rich lipoproteins. Conflicting results have been… 
Highly Cited
1993
Highly Cited
1993
Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.
We have explored the use of adenovirus-mediated gene transfer to transiently elicit production of low density lipoprotein (LDL… 
Highly Cited
1993
Highly Cited
1993
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor
Highly Cited
1993
Highly Cited
1993
Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro.
Glycoprotein 330 (gp330), a cell-surface protein that is localized in clathrin-coated pits, is structurally related to both the… 
Highly Cited
1989
Highly Cited
1989
Finnish type of low density lipoprotein receptor gene mutation (FH-Helsinki) deletes exons encoding the carboxy-terminal part of the receptor and creates an internalization-defective phenotype.
A specific type of gene mutation affecting the LDL receptor has been found in many Finnish patients with familial… 
Highly Cited
1983
Highly Cited
1983
The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor
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