LDLR gene

Known as: LDLR, familial hypercholesterolemia, LDLCQ2 
This gene plays a role in the modulation of ligand-specific receptor-mediated endocytosis, and also plays a regulatory role in cholesterol synthesis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2018
05101519752018

Papers overview

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Highly Cited
2008
Highly Cited
2008
Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer's disease-like dementia but the… (More)
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Highly Cited
2008
Highly Cited
2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low density lipoprotein receptor (LDLR) and induces its… (More)
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Highly Cited
2001
Highly Cited
2001
The low density lipoprotein receptor (LDLR) family is composed of a class of cell surface endocytic receptors that recognize… (More)
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2001
2001
Mutations in the low density lipoprotein receptor gene (LDLR) cause familial hypercholesterolaemia (FH). The FH website (http… (More)
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Highly Cited
1996
Highly Cited
1996
Lipoprotein lipase (LPL) is a key enzyme in the hydrolysis of triglyceride-rich lipoproteins. Conflicting results have been… (More)
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Highly Cited
1994
Highly Cited
1994
We completed the cDNA cloning and sequencing of gp330, the major kidney glomerular antigen for rat Heymann nephritis. The deduced… (More)
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Highly Cited
1993
Highly Cited
1993
We have explored the use of adenovirus-mediated gene transfer to transiently elicit production of low density lipoprotein (LDL… (More)
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Highly Cited
1987
Highly Cited
1987
We here describe a mutant low density lipoprotein receptor gene that produces a shortened receptor protein lacking three domains… (More)
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Highly Cited
1987
Highly Cited
1987
We found a large deletion (more than 10 kilobases) in the gene for the low-density-lipoprotein receptor in 63 percent of French… (More)
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Highly Cited
1985