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LDLR gene

Known as: LDLR, familial hypercholesterolemia, LDLCQ2 
This gene plays a role in the modulation of ligand-specific receptor-mediated endocytosis, and also plays a regulatory role in cholesterol synthesis.
National Institutes of Health

Papers overview

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2014
2014
Berberine (BBR) is an isoquinoline alkaloid isolated from several Chinese herbal medicines, such as Coptis chinensis, Berberis… Expand
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Highly Cited
2011
Highly Cited
2011
Convergent epidemiological, clinical, and experimental findings indicate that hypercholesterolemia contributes to the onset of… Expand
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2011
2011
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) at the cell surface… Expand
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2009
2009
Apolipoprotein E (apoE) and its receptor, very low density lipoprotein receptor (VLDLR), are involved in fat accumulation in… Expand
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Highly Cited
2007
Highly Cited
2007
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that regulates low density lipoprotein receptor (LDLR… Expand
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Highly Cited
2002
Highly Cited
2002
To perform vectorial secretory and transport functions that are critical for the survival of the organism, epithelial cells sort… Expand
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Highly Cited
2001
Highly Cited
2001
Mutations in the low density lipoprotein receptor gene (LDLR) cause familial hypercholesterolaemia (FH). The FH website (http… Expand
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Highly Cited
2001
Highly Cited
2001
Leptin-deficient mice (ob/ob) are an excellent murine model for obesity, insulin resistance, and diabetes, all of which are… Expand
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Highly Cited
1993
Highly Cited
1993
Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible… Expand
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Highly Cited
1993
Highly Cited
1993
We have explored the use of adenovirus-mediated gene transfer to transiently elicit production of low density lipoprotein (LDL… Expand
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