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LDLR gene

Known as: LDLR, familial hypercholesterolemia, LDLCQ2 
This gene plays a role in the modulation of ligand-specific receptor-mediated endocytosis, and also plays a regulatory role in cholesterol synthesis.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The proprotein convertase subtilisin/kexin-type 9 (PCSK9), which promotes degradation of the hepatic low density lipoprotein… Expand
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Review
2004
Review
2004
The clinical phenotype of heterozygous familial hypercholesterolemia (FH) is characterized by increased plasma levels of total… Expand
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Review
2004
Review
2004
Familial hypercholesterolemia (FH) is an autosomal disorder characterized by increased levels of total cholesterol and low… Expand
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Highly Cited
2002
Highly Cited
2002
To perform vectorial secretory and transport functions that are critical for the survival of the organism, epithelial cells sort… Expand
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Highly Cited
2001
Highly Cited
2001
Leptin-deficient mice (ob/ob) are an excellent murine model for obesity, insulin resistance, and diabetes, all of which are… Expand
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Highly Cited
2000
Highly Cited
2000
The role of macrophage lipoprotein lipase (LPL) expression in atherosclerotic lesion formation was examined in low density… Expand
Highly Cited
1993
Highly Cited
1993
  • J. Herz, R. Gerard
  • Proceedings of the National Academy of Sciences…
  • 1993
  • Corpus ID: 19837199
We have explored the use of adenovirus-mediated gene transfer to transiently elicit production of low density lipoprotein (LDL… Expand
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Highly Cited
1993
Highly Cited
1993
Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible… Expand
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Highly Cited
1993
Highly Cited
1993
Glycoprotein 330 (gp330), a cell-surface protein that is localized in clathrin-coated pits, is structurally related to both the… Expand
Highly Cited
1983
Highly Cited
1983
The receptor for low-density lipoprotein (LDL) is synthesized as a 120 kd precursor that undergoes a 40 kd posttranslational… Expand