Hyperlipoproteinemia Type IIa

Known as: Type IIa Hyperlipoproteinemia, FHC, FH 
An autosomal dominant inherited disorder characterized by very high levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2017
020406019602017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Familial hypercholesterolemia (FH) (OMIM 143890) is most commonly caused by variations in the LDLR gene which encodes the… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Patients with homozygous familial hypercholesterolemia have markedly elevated cholesterol levels, which respond poorly… (More)
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Highly Cited
2006
Highly Cited
2006
Selected missense mutations in the proprotein convertase subtilisin/kexin type 9 serine protease gene (PCSK9) cause autosomal… (More)
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Highly Cited
2006
Highly Cited
2006
Familial autosomal dominant hypercholesterolemia is associated with high risk for cardiovascular accidents and is related to… (More)
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Highly Cited
2005
Highly Cited
2005
Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in… (More)
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Highly Cited
2004
Highly Cited
2004
Proprotein convertase subtilisin kexin 9 (Pcsk9) is a subtilisin serine protease with a putative role in cholesterol metabolism… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE To assess the cardiac status of the long-term survivors and to estimate the incidence and the features of subclinical… (More)
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Highly Cited
2003
Highly Cited
2003
Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an… (More)
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Highly Cited
1973
Highly Cited
1973
To assess the genetics of hyperlipidemia in coronary heart disease, family studies were carried out in 2520 relatives and spouses… (More)
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