LDLR protein, human

Known as: LDLR, familial hypercholesterolemia protein, human, Low Density Lipoprotein Receptor 
Low-density lipoprotein receptor (860 aa, ~95 kDa) is encoded by the human LDLR gene. This protein is involved in the endocytosis of cholesterol.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
CONTEXT The diagnosis of familial hypercholesterolemia (FH) can be made using the Dutch Lipid Clinic Network criteria. This… (More)
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Highly Cited
2011
Highly Cited
2011
The human skeleton is affected by mutations in low-density lipoprotein receptor-related protein 5 (LRP5). To understand how LRP5… (More)
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Highly Cited
2010
Highly Cited
2010
Under normal physiological conditions, cellular homeostasis is partly regulated by a balance of pro- and anti-phagocytic signals… (More)
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Highly Cited
2009
Highly Cited
2009
Endoplasmic reticulum (ER) stress is a hallmark of advanced atherosclerosis, but its causative role in plaque progression is… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND The role of osteoprotegerin in vascular disease is unclear. Recent observational studies show that serum… (More)
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Review
2007
Review
2007
The recent identification of a link between bone mass in humans and gain- or loss-of-function mutations in the Wnt coreceptor low… (More)
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Review
2006
Review
2006
Biological systems have acquired effective adaptive strategies to cope with physiological challenges and to maximize biochemical… (More)
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Highly Cited
2005
Highly Cited
2005
The low-density lipoprotein receptor (LDLR) prevents hypercholesterolemia and atherosclerosis by removing low-density lipoprotein… (More)
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Highly Cited
2003
Highly Cited
2003
Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an… (More)
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Highly Cited
2000
Highly Cited
2000
The Wnt family of secreted signalling molecules are essential in embryo development and tumour formation. The Frizzled (Fz… (More)
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