Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… (More)
National Institutes of Health

Related topics

Related topics

48 relations
2 ML denileukin diftitox 0.15 MG/ML InjectionCytokine GeneCytokine Network PathwayCytokine Signaling
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Narrower (13)

ALT-801AldesleukinDAB(389)-interleukin 2DAB(486)-interleukin 2
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Broader (4)

Analgesics, Non-NarcoticAntineoplastic AgentsImmunologic AdjuvantsLymphokines

Papers overview

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Highly Cited
2008
Highly Cited
2008
A fundamental role for interleukin-21 in the generation of T follicular helper cells.
T cell help to B cells is a fundamental property of adaptive immunity, yet only recently have many of the cellular and molecular… (More)
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Highly Cited
2005
Highly Cited
2005
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant… (More)
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Review
2004
Review
2004
Tolerance, not immunity, crucially depends on IL-2
Interleukin-2 (IL-2) was identified based on its potent T-cell growth-factor activity and is widely considered to be a key… (More)
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Highly Cited
2001
Highly Cited
2001
Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway.
Clathrin-dependent endocytosis has long been presented as the only efficient mechanism by which transmembrane receptors are… (More)
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Highly Cited
2000
Highly Cited
2000
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here… (More)
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Review
1999
Review
1999
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993.
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… (More)
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Highly Cited
1999
Highly Cited
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the… (More)
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Highly Cited
1994
Highly Cited
1994
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2.
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma… (More)
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Highly Cited
1994
Highly Cited
1994
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2.
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… (More)
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Highly Cited
1993
Highly Cited
1993
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.
Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4… (More)
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