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Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous… Expand Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response… Expand Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early… Expand Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant… Expand PURPOSE
To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… Expand BACKGROUND
Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… Expand OBJECTIVE
To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma… Expand Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4… Expand A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The… Expand Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from… Expand