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Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… 
National Institutes of Health

Related topics

Related topics

48 relations
2 ML denileukin diftitox 0.15 MG/ML InjectionCytokine GeneCytokine Network PathwayCytokine Signaling

Narrower (13)

ALT-801AldesleukinDAB(389)-interleukin 2DAB(486)-interleukin 2

Broader (4)

Analgesics, Non-NarcoticAntineoplastic AgentsImmunologic AdjuvantsLymphokines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
IL-6 rescues resting mouse T cells from apoptosis.
It has previously been demonstrated that mature mouse T cells live for many weeks in vivo. In contrast, explanted lymph node or… 
Highly Cited
1997
Highly Cited
1997
Proliferation of ramified microglia on an astrocyte monolayer: Characterization of stimulatory and inhibitory cytokines
Proliferation of ramified microglia is a common phenomenon in brain pathology, but little is known about how this is regulated… 
Highly Cited
1996
Highly Cited
1996
Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
Although transfection to express any of a multitude of immunomodulatory molecules can lead to the rejection of murine tumors in… 
Review
1996
Review
1996
A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.
The interleukin 2 (IL-2) gene is subject to two types of regulation: its expression is T-lymphocyte-specific and it is acutely… 
Highly Cited
1995
Highly Cited
1995
A reassessment of the role of B7-1 expression in tumor rejection
Introduction of the B7-1 gene into murine tumor cells can result in rejection of the B7-1 transductants and, in some cases… 
Highly Cited
1992
Highly Cited
1992
Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen
The B cell activation antigen B7/BB1 has been shown to co‐stimulate growth of human T cells by binding the T cell molecule CD28… 
Review
1987
Review
1987
Regulation of human B lymphocyte activation, proliferation, and differentiation.
Highly Cited
1981
Highly Cited
1981
The persisting (P) cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells.
Histamine was detected at levels of 100 ng/10(6) cells in the metachromatic granules of the persisting (P) cell, which appears in… 
Highly Cited
1981
Highly Cited
1981
Antigen-driven helper cell-independent cloned cytolytic T lymphocytes
Cellular interactions between alloreactive cytolytic T lymphocytes (CTLs) and helper T cells have been suggested by the results… 
Highly Cited
1976
Highly Cited
1976
Proliferation of murine thymic lymphocytes in vitro is mediated by the concanavalin A-induced release of a lymphokine (costimulator).
Mitogen-induced proliferation of lymphocytes may in theory result directly from the interaction of mitogen with the cells, or… 
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