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Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… 
National Institutes of Health

Related topics

Related topics

48 relations
2 ML denileukin diftitox 0.15 MG/ML InjectionCytokine GeneCytokine Network PathwayCytokine Signaling

Narrower (13)

ALT-801AldesleukinDAB(389)-interleukin 2DAB(486)-interleukin 2

Broader (4)

Analgesics, Non-NarcoticAntineoplastic AgentsImmunologic AdjuvantsLymphokines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous… 
Review
2008
Review
2008
The biology of interleukin-2.
  • T. Malek
  • Annual Review of Immunology
  • 2008
  • Corpus ID: 45361401
Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early… 
Highly Cited
2005
Highly Cited
2005
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant… 
Review
1999
Review
1999
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993.
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… 
Highly Cited
1999
Highly Cited
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the… 
Highly Cited
1994
Highly Cited
1994
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2.
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… 
Highly Cited
1994
Highly Cited
1994
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2.
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma… 
Highly Cited
1993
Highly Cited
1993
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.
Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4… 
Highly Cited
1983
Highly Cited
1983
Structure and expression of a cloned cDNA for human interleukin-2
A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The… 
Highly Cited
1982
Highly Cited
1982
Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from… 
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