Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
T cell help to B cells is a fundamental property of adaptive immunity, yet only recently have many of the cellular and molecular… (More)
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Highly Cited
2005
Highly Cited
2005
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant… (More)
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Review
2004
Review
2004
Interleukin-2 (IL-2) was identified based on its potent T-cell growth-factor activity and is widely considered to be a key… (More)
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Highly Cited
2001
Highly Cited
2001
Clathrin-dependent endocytosis has long been presented as the only efficient mechanism by which transmembrane receptors are… (More)
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Highly Cited
2000
Highly Cited
2000
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here… (More)
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Review
1999
Review
1999
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… (More)
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Highly Cited
1999
Highly Cited
1999
The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the… (More)
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Highly Cited
1994
Highly Cited
1994
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… (More)
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Highly Cited
1993
Highly Cited
1993
Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4… (More)
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