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Interleukin-2
Known as:
T-Cell Stimulating Factor
, Interleukin 2
, T-Cell Growth Factor
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Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune…
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National Institutes of Health
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Related topics
Related topics
48 relations
2 ML denileukin diftitox 0.15 MG/ML Injection
Cytokine Gene
Cytokine Network Pathway
Cytokine Signaling
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Narrower (13)
ALT-801
Aldesleukin
DAB(389)-interleukin 2
DAB(486)-interleukin 2
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Broader (4)
Analgesics, Non-Narcotic
Antineoplastic Agents
Immunologic Adjuvants
Lymphokines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
K. Atarashi
,
T. Tanoue
,
+19 authors
K. Honda
Nature
2013
Corpus ID: 4419776
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous…
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Review
2008
Review
2008
The biology of interleukin-2.
T. Malek
Annual Review of Immunology
2008
Corpus ID: 45361401
Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early…
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Highly Cited
2005
Highly Cited
2005
A function for interleukin 2 in Foxp3-expressing regulatory T cells
J. Fontenot
,
J. P. Rasmussen
,
M. Gavin
,
A. Rudensky
Nature Immunology
2005
Corpus ID: 31983193
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant…
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Review
1999
Review
1999
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993.
M. Atkins
,
M. Lotze
,
+10 authors
S. Rosenberg
Journal of Clinical Oncology
1999
Corpus ID: 6389021
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2…
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Highly Cited
1999
Highly Cited
1999
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Haidong Dong
,
G. Zhu
,
K. Tamada
,
Lieping Chen
Nature Network Boston
1999
Corpus ID: 21397460
The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the…
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Highly Cited
1994
Highly Cited
1994
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2.
S. Rosenberg
,
J. Yannelli
,
+7 authors
D. White
Journal of the National Cancer Institute
1994
Corpus ID: 11888516
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of…
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Highly Cited
1994
Highly Cited
1994
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2.
S. Rosenberg
,
J. Yang
,
+6 authors
D. White
JAMA
1994
Corpus ID: 34925599
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma…
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Highly Cited
1993
Highly Cited
1993
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.
R. Seder
,
R. Gazzinelli
,
A. Sher
,
W. Paul
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 6228
Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4…
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Highly Cited
1983
Highly Cited
1983
Structure and expression of a cloned cDNA for human interleukin-2
T. Taniguchi
,
H. Matsui
,
+4 authors
J. Hamuro
Nature
1983
Corpus ID: 4263205
A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The…
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Highly Cited
1982
Highly Cited
1982
Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes
E. Grimm
,
A. Mazumder
,
Hua Zhang
,
S. Rosenberg
Journal of Experimental Medicine
1982
Corpus ID: 84469668
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from…
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