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Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… Expand
National Institutes of Health

Related topics

Related topics

48 relations
2 ML denileukin diftitox 0.15 MG/ML InjectionCytokine GeneCytokine Network PathwayCytokine Signaling
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Narrower (13)

ALT-801AldesleukinDAB(389)-interleukin 2DAB(486)-interleukin 2
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Broader (4)

Analgesics, Non-NarcoticAntineoplastic AgentsImmunologic AdjuvantsLymphokines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity
Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral tolerance therefore, they are key in… Expand
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Highly Cited
2013
Highly Cited
2013
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous… Expand
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Highly Cited
2005
Highly Cited
2005
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant… Expand
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Highly Cited
2001
Highly Cited
2001
Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway.
Clathrin-dependent endocytosis has long been presented as the only efficient mechanism by which transmembrane receptors are… Expand
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Highly Cited
2000
Highly Cited
2000
Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary… Expand
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Review
1999
Review
1999
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993.
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… Expand
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Highly Cited
1994
Highly Cited
1994
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2.
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… Expand
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Highly Cited
1994
Highly Cited
1994
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2.
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma… Expand
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Highly Cited
1983
Highly Cited
1983
Structure and expression of a cloned cDNA for human interleukin-2
A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The… Expand
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Highly Cited
1982
Highly Cited
1982
Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from… Expand
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