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Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous… 
Review
2008
Review
2008
  • T. Malek
  • Annual Review of Immunology
  • 2008
  • Corpus ID: 45361401
Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early… 
Highly Cited
2005
Highly Cited
2005
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant… 
Review
1999
Review
1999
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… 
Highly Cited
1999
Highly Cited
1999
The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the… 
Highly Cited
1994
Highly Cited
1994
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… 
Highly Cited
1994
Highly Cited
1994
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma… 
Highly Cited
1993
Highly Cited
1993
Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4… 
Highly Cited
1983
Highly Cited
1983
A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The… 
Highly Cited
1982
Highly Cited
1982
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from…