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Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… 
National Institutes of Health

Related topics

Related topics

48 relations
2 ML denileukin diftitox 0.15 MG/ML InjectionCytokine GeneCytokine Network PathwayCytokine Signaling

Narrower (13)

ALT-801AldesleukinDAB(389)-interleukin 2DAB(486)-interleukin 2

Broader (4)

Analgesics, Non-NarcoticAntineoplastic AgentsImmunologic AdjuvantsLymphokines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma.
Pulmonary dendritic cells (DC) can induce both tolerogenic as well as inflammatory immune responses in the lung. Conversely… 
Highly Cited
1997
Highly Cited
1997
IL-6 rescues resting mouse T cells from apoptosis.
It has previously been demonstrated that mature mouse T cells live for many weeks in vivo. In contrast, explanted lymph node or… 
Highly Cited
1997
Highly Cited
1997
Proliferation of ramified microglia on an astrocyte monolayer: Characterization of stimulatory and inhibitory cytokines
Proliferation of ramified microglia is a common phenomenon in brain pathology, but little is known about how this is regulated… 
Highly Cited
1996
Highly Cited
1996
Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
Although transfection to express any of a multitude of immunomodulatory molecules can lead to the rejection of murine tumors in… 
Review
1996
Review
1996
A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation.
The interleukin 2 (IL-2) gene is subject to two types of regulation: its expression is T-lymphocyte-specific and it is acutely… 
Highly Cited
1995
Highly Cited
1995
A reassessment of the role of B7-1 expression in tumor rejection
Introduction of the B7-1 gene into murine tumor cells can result in rejection of the B7-1 transductants and, in some cases… 
Highly Cited
1992
Highly Cited
1992
Co‐stimulation of murine CD4 T cell growth: cooperation between B7 and heat‐stable antigen
The B cell activation antigen B7/BB1 has been shown to co‐stimulate growth of human T cells by binding the T cell molecule CD28… 
Highly Cited
1981
Highly Cited
1981
The persisting (P) cell: histamine content, regulation by a T cell-derived factor, origin from a bone marrow precursor, and relationship to mast cells.
Histamine was detected at levels of 100 ng/10(6) cells in the metachromatic granules of the persisting (P) cell, which appears in… 
Highly Cited
1981
Highly Cited
1981
Antigen-driven helper cell-independent cloned cytolytic T lymphocytes
Cellular interactions between alloreactive cytolytic T lymphocytes (CTLs) and helper T cells have been suggested by the results… 
Highly Cited
1976
Highly Cited
1976
Proliferation of murine thymic lymphocytes in vitro is mediated by the concanavalin A-induced release of a lymphokine (costimulator).
Mitogen-induced proliferation of lymphocytes may in theory result directly from the interaction of mitogen with the cells, or… 
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