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Interleukin-2

Known as: T-Cell Stimulating Factor, Interleukin 2, T-Cell Growth Factor 
Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune… Expand
National Institutes of Health

Related topics

Related topics

48 relations
2 ML denileukin diftitox 0.15 MG/ML InjectionCytokine GeneCytokine Network PathwayCytokine Signaling
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Narrower (13)

ALT-801AldesleukinDAB(389)-interleukin 2DAB(486)-interleukin 2
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Broader (4)

Analgesics, Non-NarcoticAntineoplastic AgentsImmunologic AdjuvantsLymphokines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous… Expand
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Review
2013
Review
2013
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response… Expand
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Review
2008
Review
2008
The biology of interleukin-2.
  • T. Malek
  • Annual review of immunology
  • 2008
    • Corpus ID: 45361401
Much data support an essential role for interleukin (IL)-2 in immune tolerance. This idea is much different from the early… Expand
Highly Cited
2005
Highly Cited
2005
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant… Expand
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Review
1999
Review
1999
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993.
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… Expand
Highly Cited
1994
Highly Cited
1994
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2.
BACKGROUND Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of… Expand
Highly Cited
1994
Highly Cited
1994
Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2.
OBJECTIVE To determine the efficacy of treatment using high-dose bolus interleukin 2 (IL-2) in patients with metastatic melanoma… Expand
Highly Cited
1993
Highly Cited
1993
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.
Naive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma). In vitro, they develop into IL-4… Expand
Highly Cited
1983
Highly Cited
1983
Structure and expression of a cloned cDNA for human interleukin-2
A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The… Expand
Highly Cited
1982
Highly Cited
1982
Lymphokine-activated killer cell phenomenon. Lysis of natural killer- resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes
Activation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from… Expand
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