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- Publications
- Influence
Immunobiology: The Immune System in Health and Disease
- C. Janeway
- Medicine, Biology
- 1 April 1996
Introductory immunology textbook for medical students, advanced undergraduates, and graduate students.
Janeway's immunobiology
- K. P. Murphy, Casey T. Weaver, +5 authors M. Walport
- Biology
- 2007
Part I An Introduction to Immunobiology and Innate Immunity 1. Basic Concepts in Immunology 2. Innate Immunity Part II The Recognition of Antigen 3. Antigen Recognition by B-cell and T-cell Receptors… Expand
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
- R. Medzhitov, P. Preston-Hurlburt, C. Janeway
- Biology, Medicine
- Nature
- 24 July 1997
Induction of the adaptive immune response depends on the expression of co-stimulatory molecules and cytokines by antigen-presenting cells. The mechanisms that control the initial induction of these… Expand
Innate immune recognition.
- C. Janeway, R. Medzhitov
- Biology, Medicine
- Annual review of immunology
- 2002
The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved… Expand
Approaching the asymptote? Evolution and revolution in immunology.
- C. Janeway
- Biology, Medicine
- Cold Spring Harbor symposia on quantitative…
- 1989
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
- R. Medzhitov, P. Preston-Hurlburt, +4 authors C. Janeway
- Biology, Medicine
- Molecular cell
- 1 August 1998
The Toll-mediated signaling cascade using the NF-kappaB pathway has been shown to be essential for immune responses in adult Drosophila, and we recently reported that a human homolog of the… Expand
Innate Immunity: The Virtues of a Nonclonal System of Recognition
- R. Medzhitov, C. Janeway
- Biology, Medicine
- Cell
- 31 October 1997
One of the predictions of the clonal selection theory was the ability of mature peripheral lymphocytes to discriminate between self and nonself. All self-reactive lymphocytes were thought to be… Expand
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling
- K. Kobayashi, L. Hernandez, J. Galán, C. Janeway, R. Medzhitov, R. Flavell
- Medicine, Biology
- Cell
- 26 July 2002
Toll-like receptors (TLRs) detect microorganisms and protect multicellular organisms from infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase IRAK. The IRAK family… Expand
Decoding the Patterns of Self and Nonself by the Innate Immune System
- R. Medzhitov, C. Janeway
- Biology, Medicine
- Science
- 12 April 2002
The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and… Expand
Phylogenetic perspectives in innate immunity.
- J. Hoffmann, F. Kafatos, C. Janeway, R. A. Ezekowitz
- Biology, Medicine
- Science
- 21 May 1999
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities… Expand
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