C. Janeway

Publications704
h-index110
Citations73,700
Highly Influential Citations2,520
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Immunobiology: The Immune System in Health and Disease
Introductory immunology textbook for medical students, advanced undergraduates, and graduate students.
Janeway's immunobiology
TLDR
The Evolution of the Immune System Appendix I Immunologists' Toolbox Appendix II CD Antigens Appendix III Cytokines and their Receptors Appendix IV Chemokinesand their Receptionors Appendix V Immunological Constants.
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TLDR
The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
Innate immune recognition.
TLDR
Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
Approaching the asymptote? Evolution and revolution in immunology.
  • C. Janeway
  • Biology, Medicine
    Cold Spring Harbor symposia on quantitative…
  • 1989
Innate Immunity: The Virtues of a Nonclonal System of Recognition
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling
Decoding the Patterns of Self and Nonself by the Innate Immune System
The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and…
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.
TLDR
The monoclonal anti-Sm antibody gives the same immunoprecipitation pattern, providing direct evidence that the Sm antigen resides on all these RNA-protein complexes, which will be valuable in deciphering the biological function of these ubiquitous small nuclear RNPs.
Phylogenetic perspectives in innate immunity.
TLDR
In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
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