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Immunobiology: The Immune System in Health and Disease
Introductory immunology textbook for medical students, advanced undergraduates, and graduate students.
  • 4,459
  • 397
Janeway's immunobiology
Part I An Introduction to Immunobiology and Innate Immunity 1. Basic Concepts in Immunology 2. Innate Immunity Part II The Recognition of Antigen 3. Antigen Recognition by B-cell and T-cell ReceptorsExpand
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  • 284
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Induction of the adaptive immune response depends on the expression of co-stimulatory molecules and cytokines by antigen-presenting cells. The mechanisms that control the initial induction of theseExpand
  • 5,559
  • 245
Innate immune recognition.
The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolvedExpand
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Approaching the asymptote? Evolution and revolution in immunology.
  • C. Janeway
  • Biology, Medicine
  • Cold Spring Harbor symposia on quantitative…
  • 1989
  • 2,856
  • 111
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
The Toll-mediated signaling cascade using the NF-kappaB pathway has been shown to be essential for immune responses in adult Drosophila, and we recently reported that a human homolog of theExpand
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Innate Immunity: The Virtues of a Nonclonal System of Recognition
One of the predictions of the clonal selection theory was the ability of mature peripheral lymphocytes to discriminate between self and nonself. All self-reactive lymphocytes were thought to beExpand
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IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling
Toll-like receptors (TLRs) detect microorganisms and protect multicellular organisms from infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase IRAK. The IRAK familyExpand
  • 1,041
  • 70
  • PDF
Decoding the Patterns of Self and Nonself by the Innate Immune System
The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal andExpand
  • 1,979
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Phylogenetic perspectives in innate immunity.
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similaritiesExpand
  • 2,423
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  • PDF
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