A reassessment of the role of B7-1 expression in tumor rejection

  title={A reassessment of the role of B7-1 expression in tumor rejection},
  author={T. C. Wu and Alex Y Huang and Elizabeth M. Jaffee and Hyam I. Levitsky and Drew Mark Pardoll},
  journal={The Journal of Experimental Medicine},
  pages={1415 - 1421}
Introduction of the B7-1 gene into murine tumor cells can result in rejection of the B7-1 transductants and, in some cases, systemic immunity to subsequent challenge with the nontransduced tumor cells. These effects have been largely attributed to the function of B7-1 as a costimulator in directly activating tumor specific, major histocompatibility class I-restricted CD8+ T cells. We examined the role of B7-1 expression in the direct rejection as well as in the induction of systemic immunity to… CONTINUE READING

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