Aldesleukin

Known as: Interleukin-2(2-133),125-ser, aldesleukin [Chemical/Ingredient], Recombinant Human IL-2 
A recombinant analog of the endogenous cytokine interleukin-2 (IL-2) with immunoregulatory and antineoplastic activities. Aldesleukin binds to and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and mortality and is a common complication… (More)
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Highly Cited
2011
Highly Cited
2011
Human Vγ2 Vδ2-bearing T cells have recently received much attention in cancer immunotherapy. In this study, we conducted a phase… (More)
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Highly Cited
2010
Highly Cited
2010
Immunotherapeutic ablation of lymphoma is a conceptually attractive treatment strategy that is the subject of intense… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Renal cell cancer and malignant melanoma are two types of cancer that are responsive to immunotherapy. In this phase I… (More)
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Highly Cited
2006
Highly Cited
2006
Chimeric antigen receptors (CAR) combine an antigen-binding domain with a CD3-zeta signaling motif to redirect T-cell specificity… (More)
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Review
1999
Review
1999
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… (More)
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Highly Cited
1996
Highly Cited
1996
Allogeneic bone marrow transplantation (BMT) is the only effective treatment for hematologic malignancies resistant to… (More)
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Highly Cited
1995
Highly Cited
1995
PURPOSE To determine the efficacy and toxicity of a high-dose interleukin-2 (IL-2) regimen in patients with metastatic renal cell… (More)
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Highly Cited
1987
Highly Cited
1987
Regulation of the production of the biologically active vitamin D3 sterol 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] by cultured… (More)
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Highly Cited
1984
Highly Cited
1984
The gene for interleukin-2 was isolated from the Jurkat cell line and from normal peripheral blood lymphocytes and, when inserted… (More)
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