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Aldesleukin

Known as: Interleukin-2(2-133),125-ser, aldesleukin [Chemical/Ingredient], Recombinant Human IL-2 
A recombinant analog of the endogenous cytokine interleukin-2 (IL-2) with immunoregulatory and antineoplastic activities. Aldesleukin binds to and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and mortality and is a common complication… Expand
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Highly Cited
2010
Highly Cited
2010
Immunotherapeutic ablation of lymphoma is a conceptually attractive treatment strategy that is the subject of intense… Expand
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Highly Cited
2006
Highly Cited
2006
Chimeric antigen receptors (CAR) combine an antigen-binding domain with a CD3-zeta signaling motif to redirect T-cell specificity… Expand
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Review
1999
Review
1999
PURPOSE To determine the short- and long-term efficacy and toxicity of the high-dose intravenous bolus interleukin 2 (IL-2… Expand
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Highly Cited
1998
Highly Cited
1998
Background Recombinant human interleukin-2 (aldesleukin) and recombinant human interferon alfa can induce notable tumor… Expand
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Review
1997
Review
1997
Despite significant advances in understanding the biology of renal cell carcinoma (RCC) during the past decade, metastatic… Expand
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Highly Cited
1996
Highly Cited
1996
Allogeneic bone marrow transplantation (BMT) is the only effective treatment for hematologic malignancies resistant to… Expand
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Highly Cited
1995
Highly Cited
1995
PURPOSE To determine the efficacy and toxicity of a high-dose interleukin-2 (IL-2) regimen in patients with metastatic renal cell… Expand
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Highly Cited
1990
Highly Cited
1990
We describe the production and characterization of three mAb to transforming growth factor-beta (TGF-beta) and the use of two of… Expand
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Highly Cited
1984
Highly Cited
1984
The gene for interleukin-2 was isolated from the Jurkat cell line and from normal peripheral blood lymphocytes and, when inserted… Expand
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