W. Hennink

Publications657
h-index98
Citations40,802
Highly Influential Citations660
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Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress.
Many different systems and strategies have been evaluated for drug targeting to tumors over the years. Routinely used systems include liposomes, polymers, micelles, nanoparticles and antibodies, and… Expand
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25th anniversary article: Engineering hydrogels for biofabrication.
With advances in tissue engineering, the possibility of regenerating injured tissue or failing organs has become a realistic prospect for the first time in medical history. Tissue engineering - the… Expand
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Protein Instability in Poly(Lactic-co-Glycolic Acid) Microparticles
In this review the current knowledge of protein degradation during preparation, storage and release from poly(lactic-co-glycolic acid) (PLGA) microparticles is described, as well as stabilization… Expand
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Cationic Polymer Based Gene Delivery Systems
Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers… Expand
  • 756
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Hydrogels for protein delivery.
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Tumour-targeted nanomedicines: principles and practice
Drug targeting systems are nanometre-sized carrier materials designed for improving the biodistribution of systemically applied (chemo)therapeutics. Various different tumour-targeted nanomedicines… Expand
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Novel crosslinking methods to design hydrogels.
Hydrogels are presently under investigation as matrices for the controlled release of bioactive molecules, in particular pharmaceutical proteins, and for the encapsulation of living cells. For these… Expand
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Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.
In this study, the potential of N-trimethyl chitosan (TMC) nanoparticles as a carrier system for the nasal delivery of proteins was investigated. TMC nanoparticles were prepared by ionic crosslinking… Expand
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Biodegradable polymers as non-viral carriers for plasmid DNA delivery.
Gene therapy holds a great promise for the treatment of acquired and inherited diseases with a genetic origin that are currently incurable. Non-viral gene delivery systems are gaining recognition as… Expand
  • 400
  • 9
Hydrogels in a historical perspective: from simple networks to smart materials.
Over the past decades, significant progress has been made in the field of hydrogels as functional biomaterials. Biomedical application of hydrogels was initially hindered by the toxicity of… Expand
  • 398
  • 8