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DAB(389)-interleukin 2

Known as: DAB389IL2, DAB(389)IL-2, DAB(389)-Interleukin-2 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Diphtheria ToxinInterleukin-2Recombinant Fusion Proteinsdenileukin diftitox

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice.
PURPOSE The novel fusion protein, DAB389EGF, composed of the catalytic and translocation domains of diphtheria toxin (DAB389… 
Highly Cited
2003
Highly Cited
2003
Diphtheria toxin-interleukin-3 fusion protein (DT388IL3) prolongs disease-free survival of leukemic immunocompromised mice
The novel fusion protein DT388IL3, composed of the catalytic and translocation domains of diphtheria toxin (DT388) fused with a… 
Highly Cited
2001
Highly Cited
2001
A multicenter dose-escalation trial with denileukin diftitox (ONTAK, DAB(389)IL-2) in patients with severe psoriasis.
BACKGROUND Denileukin diftitox, a fusion protein targeting both malignant and normal activated lymphocytes, has been shown… 
Review
2000
Review
2000
DAB(389)IL-2 (denileukin diftitox, ONTAK): a new fusion protein technology.
Genetic engineering has led to the development of fusion protein toxins, which are targeted effector molecules that combine a… 
Highly Cited
1998
Highly Cited
1998
Treatment of psoriasis with interleukin-10.
1998
1998
Immunotherapy of experimental autoimmune myasthenia gravis: selective effects of CTLA4Ig and synergistic combination with an IL2-Diphtheria toxin fusion protein
Review
1997
Review
1997
Interleukin-2 fusion protein: an investigational therapy for interleukin-2 receptor expressing malignancies.
Highly Cited
1996
Highly Cited
1996
Interleukin 2 (IL-2) receptor expression and sensitivity to diphteria fusion toxin DAB389IL-2 in cultured hematopoietic cells.
The high-affinity interleukin 2 (IL-2) receptor is a heterotrimer consisting of alpha, beta, and gamma subunits. We examined the… 
Review
1995
Review
1995
Targeting diphtheria toxin to growth factor receptors.
Biochemical, genetic and X-ray crystallographic analysis of diphtheria toxin have demonstrated that the native toxin is composed… 
1991
1991
Impact of interleukin‐2‐receptor‐targeted cytotoxins on a unique model of murine interleukin‐2‐receptor‐expressing malignancy
DAB486IL‐2 is a genetically engineered fusion protein consisting of a portion of diphtheria toxin fused to human IL‐2. It is… 
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