denileukin diftitox

Known as: Diphtheria toxin precursor, NAD(+--diphthamide ADP- ribosyltransferase), Interleukin-2 Fusion Protein 
A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
PURPOSE This phase III, placebo-controlled, randomized trial was designed to investigate efficacy and safety of two doses of… (More)
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Highly Cited
2009
Highly Cited
2009
Acute graft-versus-host disease (aGVHD) is the primary limitation of allogeneic hematopoietic cell transplantation… (More)
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Highly Cited
2007
Highly Cited
2007
CD4+CD25+Foxp3+ regulatory T (Treg) cells have been implicated in the lack of effective antitumor immunity. Denileukin diftitox… (More)
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2007
2007
This phase II study evaluated the safety and efficacy of denileukin diftitox, an interleukin-2-diphtheria toxin fusion protein… (More)
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Review
2006
Review
2006
Denileukin diftitox (ONTAK; Seragen Inc, San Diego, CA) is a fusion protein designed to direct the cytocidal action of diphtheria… (More)
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Review
2006
Review
2006
Denileukin diftitox (Ontak) is a novel recombinant fusion protein consisting of peptide sequences for the enzymatically active… (More)
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Highly Cited
2005
Highly Cited
2005
Elimination of regulatory T lymphocytes may provide a way to break self-tolerance and unleash the anti-tumor properties of… (More)
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Highly Cited
2005
Highly Cited
2005
In this study, we investigated whether elimination of CD4+/CD25+ Tregs using the recombinant IL-2 diphtheria toxin conjugate DAB… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE The objective of this phase III study was to determine the efficacy, safety, and pharmacokinetics of denileukin diftitox… (More)
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Review
2000
Review
2000
Denileukin diftitox is a novel interleukin-2 receptor (IL-2R)-targeted diphtheria toxin. It binds to cells expressing IL-2R and… (More)
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