Immunoglobulin Class Switching

Known as: Class Switchings, Immunoglobulin, Switchings, Isotype, Class Switching 
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the… (More)
National Institutes of Health

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Broader (1)

Gene Rearrangement
Genes, ImmunoglobulinImmunoglobulin Switch Regionaspects of radiation effectsphysiological aspects
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Papers overview

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Review
2008
Review
2008
Mechanism and regulation of class switch recombination.
Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a… (More)
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Highly Cited
2007
Highly Cited
2007
Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL.
Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of… (More)
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Highly Cited
2002
Highly Cited
2002
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by… (More)
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Highly Cited
2000
Highly Cited
2000
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation… (More)
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Highly Cited
1997
Highly Cited
1997
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.
Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and… (More)
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Review
1996
Review
1996
Immunoglobulin class switching.
Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to… (More)
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Highly Cited
1996
Highly Cited
1996
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines… (More)
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Highly Cited
1995
Highly Cited
1995
Switch transcripts in immunoglobulin class switching.
B cells can exchange gene segments for the constant region of the immunoglobulin heavy chain, altering the class and effector… (More)
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Highly Cited
1994
Highly Cited
1994
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known to provide an essential costimulatory… (More)
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Highly Cited
1993
Highly Cited
1993
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.
We have employed a method based on the Cre-loxP recombination system of bacteriophage P1 to generate a mouse strain in which the… (More)
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