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Immunoglobulin Class Switching
Known as:
Class Switchings, Immunoglobulin
, Switchings, Isotype
, Class Switching
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Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the…
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National Institutes of Health
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Related topics
Related topics
7 relations
Broader (1)
Gene Rearrangement
Genes, Immunoglobulin
Immunoglobulin Switch Region
aspects of radiation effects
physiological aspects
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
AID from bony fish catalyzes class switch recombination
Vasco M. Barreto
,
Q. Pan-Hammarstrom
,
Yaofeng Zhao
,
Lennart Hammarstrom
,
Z. Misulovin
,
M. Nussenzweig
Journal of Experimental Medicine
2005
Corpus ID: 6834052
Class switch recombination was the last of the lymphocyte-specific DNA modification reactions to appear in the evolution of the…
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Review
1999
Review
1999
Regulated genomic instability and neoplasia in the lymphoid lineage.
G. Vanasse
,
Patrick Concannon
,
D. Willerford
Blood
1999
Corpus ID: 39061014
A DAPTIVE IMMUNITY in mammals depends on the generation of a vast repertoire of Ig and T-cell receptor (TCR) specificities…
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Highly Cited
1998
Highly Cited
1998
Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help.
A. Macaulay
,
R. DeKruyff
,
D. Umetsu
Journal of Immunology
1998
Corpus ID: 5628839
B cells are effective in presenting Ag to primed T cells, but a specific role for B cells in priming naive T cells has not been…
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Highly Cited
1996
Highly Cited
1996
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions
A. Oxenius
,
K. Campbell
,
+5 authors
Martin F. Bachmann
Journal of Experimental Medicine
1996
Corpus ID: 15355281
CD40-CD40 ligand (CD40L) interaction is required for the generation of antibody responses to T-dependent antigens as well as for…
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Highly Cited
1994
Highly Cited
1994
IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.
R. Stack
,
D. Lenschow
,
Gary S. Gray
,
J. Bluestone
,
F. W. Fitch
Journal of Immunology
1994
Corpus ID: 23284787
IL-4 has been shown to be involved in the early stages of B cell maturation. Changes induced by IL-4 include cell enlargement…
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Highly Cited
1993
Highly Cited
1993
Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells.
C. Snapper
,
H. Yamada
,
D. Smoot
,
R. Sneed
,
Andrew Lees
,
James J. Mond
Journal of Immunology
1993
Corpus ID: 1273236
We have previously demonstrated that activation of murine B cells by dextran-conjugated anti-IgD antibodies may serve as a…
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Highly Cited
1992
Highly Cited
1992
Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors.
A. Fluckiger
,
J. Rossi
,
A. Bussel
,
P. Bryon
,
J. Banchereau
,
T. Defrance
Blood
1992
Corpus ID: 19353889
Recent studies performed in the laboratory have established that interleukin-4 (IL-4) used in combination with anti-CD40…
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Highly Cited
1991
Highly Cited
1991
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.
P. Shockett
,
J. Stavnezer
Journal of Immunology
1991
Corpus ID: 2504069
H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of the specific switch region that will…
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Highly Cited
1982
Highly Cited
1982
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line
F. Alt
,
N. Rosenberg
,
Rose J. Casanova
,
E. Thomas
,
D. Baltimore
Nature
1982
Corpus ID: 4356730
A cell line that switches from μ to γ2b synthesis during growth in culture uses the same VH region for both heavy chains but…
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Highly Cited
1982
Highly Cited
1982
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.
T. Nikaido
,
Y. Yamawaki‐Kataoka
,
T. Honjo
Journal of Biological Chemistry
1982
Corpus ID: 24471055
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