Immunoglobulin Class Switching

Known as: Class Switchings, Immunoglobulin, Switchings, Isotype, Class Switching 
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the… (More)
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a… (More)
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Highly Cited
2007
Highly Cited
2007
Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of… (More)
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Highly Cited
2002
Highly Cited
2002
Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by… (More)
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Highly Cited
2000
Highly Cited
2000
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation… (More)
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Highly Cited
1997
Highly Cited
1997
Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and… (More)
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Review
1996
Review
1996
Antibody class switching is induced by B-cell activators in the presence of cytokines. The identity of the heavy-chain class to… (More)
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Highly Cited
1996
Highly Cited
1996
SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines… (More)
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Highly Cited
1995
Highly Cited
1995
B cells can exchange gene segments for the constant region of the immunoglobulin heavy chain, altering the class and effector… (More)
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Highly Cited
1994
Highly Cited
1994
An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known to provide an essential costimulatory… (More)
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Highly Cited
1993
Highly Cited
1993
We have employed a method based on the Cre-loxP recombination system of bacteriophage P1 to generate a mouse strain in which the… (More)
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