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Immunoglobulin Class Switching

Known as: Class Switchings, Immunoglobulin, Switchings, Isotype, Class Switching 
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (1)

Gene Rearrangement
Genes, ImmunoglobulinImmunoglobulin Switch Regionaspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2005
Highly Cited
2005
AID from bony fish catalyzes class switch recombination
Class switch recombination was the last of the lymphocyte-specific DNA modification reactions to appear in the evolution of the… 
Review
1999
Review
1999
Regulated genomic instability and neoplasia in the lymphoid lineage.
A DAPTIVE IMMUNITY in mammals depends on the generation of a vast repertoire of Ig and T-cell receptor (TCR) specificities… 
Highly Cited
1998
Highly Cited
1998
Antigen-primed T cells from B cell-deficient JHD mice fail to provide B cell help.
B cells are effective in presenting Ag to primed T cells, but a specific role for B cells in priming naive T cells has not been… 
Highly Cited
1996
Highly Cited
1996
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions
CD40-CD40 ligand (CD40L) interaction is required for the generation of antibody responses to T-dependent antigens as well as for… 
Highly Cited
1994
Highly Cited
1994
IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.
IL-4 has been shown to be involved in the early stages of B cell maturation. Changes induced by IL-4 include cell enlargement… 
Highly Cited
1993
Highly Cited
1993
Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells.
We have previously demonstrated that activation of murine B cells by dextran-conjugated anti-IgD antibodies may serve as a… 
Highly Cited
1992
Highly Cited
1992
Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors.
Recent studies performed in the laboratory have established that interleukin-4 (IL-4) used in combination with anti-CD40… 
Highly Cited
1991
Highly Cited
1991
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.
H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of the specific switch region that will… 
Highly Cited
1982
Highly Cited
1982
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line
A cell line that switches from μ to γ2b synthesis during growth in culture uses the same VH region for both heavy chains but… 
Highly Cited
1982
Highly Cited
1982
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.
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