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Immunoglobulin Switch Region

Known as: Regions, Immunoglobulin Switch, Sequence, Ig Switch, Ig Switch Sequences 
A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or… 
National Institutes of Health

Related topics

Related topics

4 relations
ChromosomesImmunoglobulin Class Switchingaspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
G4 DNA: at risk in the genome
Regions bearing G‐quadruplex (G4) DNA motifs can be sites of genomic instability and are frequently depleted in streamlined… 
2008
2008
Automatic Gate Biasing of an SCCMOS Power Switch Achieving Maximum Leakage Reduction and Lowering Leakage Current Variability
Power switch transistors are very effective in cutting the leakage currents of digital circuits in a deep-freeze mode, by de… 
Highly Cited
2003
Highly Cited
2003
Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination
Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline, GL) Sμ segments in… 
Highly Cited
2001
Highly Cited
2001
Quantitative Regulation of Class Switch Recombination by Switch Region Transcription
The isotype specificity of immunoglobulin (Ig) class switching is regulated by a cytokine which induces transcription of a… 
1999
1999
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines.
1994
1994
Regulation and targeting of recombination in extrachromosomal substrates carrying immunoglobulin switch region sequences.
We have used extrachromosomal substrates carrying immunoglobulin heavy-chain S mu and S gamma 3 switch region sequences to study… 
1990
1990
Detection of an immunoglobulin switch region-specific DNA-binding protein in mitogen-stimulated mouse splenic B cells
We have detected a nuclear protein from lipopolysaccharide- and dextran sulfate-stimulated mouse splenic B cells which binds… 
Highly Cited
1984
Highly Cited
1984
Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange
Highly Cited
1982
Highly Cited
1982
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.
Highly Cited
1981
Highly Cited
1981
Multiple immunoglobulin switch region homologies outside the heavy chain constant region locus
Somatic rearrangement of gene segments enables higher organisms to generate additional genetic diversity from an essentially… 
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