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- Publications
- Influence
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
- R. Clynes, T. Towers, L. Presta, J. Ravetch
- Biology, Medicine
- Nature Medicine
- 30 March 2000
Inhibitory receptors have been proposed to modulate the in vivo cytotoxic response against tumor targets for both spontaneous and antibody-dependent pathways. Using a variety of syngenic and… Expand
Fcgamma receptors as regulators of immune responses.
- F. Nimmerjahn, J. Ravetch
- Medicine
- Nature reviews. Immunology
- 2008
In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs). In recent years, significant progress has been made in… Expand
Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
- Y. Kaneko, F. Nimmerjahn, J. Ravetch
- Chemistry, Medicine
- Science
- 4 August 2006
Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs). One class of Fc-FcgR interactions generates… Expand
Fcγ receptors as regulators of immune responses
- F. Nimmerjahn, J. Ravetch
- Biology
- Nature Reviews Immunology
- 2008
In addition to their role in binding antigen, antibodies can regulate immune responses through interacting with Fc receptors (FcRs). In recent years, significant progress has been made in… Expand
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
- D. Hawiger, K. Inaba, +6 authors M. Nussenzweig
- Biology, Medicine
- The Journal of experimental medicine
- 17 September 2001
Dendritic cells (DCs) have the capacity to initiate immune responses, but it has been postulated that they may also be involved in inducing peripheral tolerance. To examine the function of DCs in the… Expand
Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding
- F. Nimmerjahn, J. Ravetch
- Biology, Medicine
- Science
- 2 December 2005
Subclasses of immunoglobulin G (IgG) display substantial differences in their ability to mediate effector responses, contributing to variable activity of antibodies against microbes and tumors. We… Expand
Immune inhibitory receptors.
- J. Ravetch, L. Lanier
- Biology, Medicine
- Science
- 6 October 2000
With the detailed description and analysis of several inhibitory receptor systems on lymphoid and myeloid cells, a central paradigm has emerged in which the pairing of activation and inhibition is… Expand
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
- Tyler R. Simpson, F. Li, +11 authors S. Quezada
- Biology, Medicine
- The Journal of experimental medicine
- 26 August 2013
Anti–CTLA-4 antibody induces selective depletion of T reg cells within tumor lesions in a manner that is dependent on the presence of Fc gamma receptor-expressing macrophages within the tumor… Expand
FcgammaRIV: a novel FcR with distinct IgG subclass specificity.
- F. Nimmerjahn, P. Bruhns, Ken-ichi Horiuchi, J. Ravetch
- Medicine
- Immunity
- 2005
Mouse IgG subclasses display a hierarchy of in vivo activities, with IgG2a and IgG2b showing the greatest protective and pathogenic properties. These enhanced activities result, in part, from their… Expand
Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo
- D. J. Dilillo, G. Tan, P. Palese, J. Ravetch
- Biology, Medicine
- Nature Medicine
- 1 February 2014
Neutralizing antibodies against influenza viruses have traditionally been thought to provide protection exclusively through their variable region; the contributions of mechanisms conferred by the Fc… Expand
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