Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
It is demonstrated that Fc-receptor-dependent mechanisms contribute substantially to the action of cytotoxic antibodies against tumors and indicate that an optimal antibody against tumors would bind preferentially to activation Fc receptors and minimally to the inhibitory partner FcγRIIB.
Fcgamma receptors as regulators of immune responses.
Recent studies addressing the multifaceted roles of FcRs for IgG (FcgammaRs) in the immune system and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases are discussed.
Fcγ receptors as regulators of immune responses
Recent studies addressing the multifaceted roles of FcRs for IgG (FcγRs) in the immune system are discussed and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases are discussed.
Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
It is shown that IgG acquires anti-inflammatory properties upon Fc sialylation, which is reduced upon the induction of an antigen-specific immune response, and may provide a switch from innate anti- inflammatory activity in the steady state to generating adaptive pro-inflammatory effects upon antigenic challenge.
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
An antigen delivery system targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
Immune inhibitory receptors.
A central paradigm has emerged in which the pairing of activation and inhibition is necessary to initiate, amplify, and then terminate immune responses in mice with targeted disruption of inhibitory receptors.
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
Anti–CTLA-4 antibody induces selective depletion of T reg cells within tumor lesions in a manner that is dependent on the presence of Fc gamma receptor-expressing macrophages within the tumor…
Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding
The mechanism underlying this long-standing observation of subclass dominance in function is provided by the differential affinities of IgG subclasses for specific activating IgG Fc receptors compared with their affinITIES for the inhibitory IgGFc receptor.
FcgammaRIV: a novel FcR with distinct IgG subclass specificity.
The FcgammaR system has evolved distinct activation receptors displaying selectivity for IgG subclasses, with IgG1 antibodies exclusively dependent on FcGammaRIII, whereas IgG 2a and IgG2b show preferential dependence on F cgamma RIV activation.
γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins
The molecular cloning and characterization of a gene regulated by rIFN-γ in U937 cells as well as in human mononuclear cells, fibroblasts and endothelial cells is reported here and may be a member of a family of proteins involved in the inflammatory process.