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Blimp1 is a critical determinant of the germ cell lineage in mice
TLDR
It is shown that Blimp1 (also known as Prdm1), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation.
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
TLDR
This work targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies and found that this difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.
In Vivo Analysis of Dendritic Cell Development and Homeostasis
TLDR
It is shown that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs, but not monocytes, and finally to committed precursor of cDCs (pre-cDCs).
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
TLDR
It is shown that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA ligase 4, illustrating that HR and NHEJ compete to process DNA breaks that arise during DNA replication.
Genomic Instability in Mice Lacking Histone H2AX
TLDR
Higher order chromatin structure presents a barrier to the recognition and repair of DNA damage, and H2AX is critical for facilitating the assembly of specific DNA-repair complexes on damaged DNA.
Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter
TLDR
It is found that B cell division is restricted to the DZ, with a net vector of B cell movement from the D Z to the LZ, and T cell help, and not direct competition for antigen, is the limiting factor in GC selection.
Tolerogenic dendritic cells.
TLDR
It is suggested that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs.
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
TLDR
An antigen delivery system targeting these specialized antigen presenting cells in vivo using a monoclonal antibody to a DC-restricted endocytic receptor is devised, which concludes that in the absence of additional stimuli DCs induce transient antigen-specific T cell activation followed by T cell deletion and unresponsiveness.
Inducing and expanding regulatory T cell populations by foreign antigen
TLDR
The conversion of truly naive CD4+ T cells into suppressor cells expressing Foxp3 is reported by targeting of peptide-agonist ligands to dendritic cells and by analysis of Foxp 3 expression at the level of single cells, showing that conversion was achieved by minute antigen doses with suboptimal dendrite cell activation.
H2AX: the histone guardian of the genome.
TLDR
A model in which chromatin restructuring mediated by H2AX phosphorylation serves to concentrate DNA repair/signaling factors and/or tether DNA ends together, which could explain the pleotropic phenotypes observed in its absence is suggested.
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