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H2AX protein, human

Known as: H2A/X, H2A.X, H2AX 
Histone H2AX (143 aa, ~15 kDa) is encoded by the human H2AFX gene. This protein plays a role in nucleosome formation and V(D)J recombination.
National Institutes of Health

Related topics

Related topics

11 relations
Cell NucleusDouble Strand Break RepairH2AFX geneH2AFX wt Allele

Broader (1)

Histones

Papers overview

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Highly Cited
2008
Highly Cited
2008
Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation
Stem cell self-renewal implies proliferation under continued maintenance of multipotency. Small changes in numbers of stem cells… 
Highly Cited
2006
Highly Cited
2006
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at… 
Highly Cited
2006
Highly Cited
2006
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Highly Cited
2004
Highly Cited
2004
Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy*
Based on the role of phosphorylation of the histone H2A variant H2AX in recruitment of DNA repair and checkpoint proteins to the… 
Highly Cited
2004
Highly Cited
2004
Radiation Sensitivity, H2AX Phosphorylation, and Kinetics of Repair of DNA Strand Breaks in Irradiated Cervical Cancer Cell Lines
Six human cervical cancer cell lines [five human papillomavirus (HPV) positive, one HPV negative] for induction and rejoining of… 
Highly Cited
2004
Highly Cited
2004
The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks
ABSTRACT Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer… 
Highly Cited
2004
Highly Cited
2004
Control of sister chromatid recombination by histone H2AX.
Highly Cited
2002
Highly Cited
2002
DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1
Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR… 
Highly Cited
2002
Highly Cited
2002
NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain
Highly Cited
2002
Highly Cited
2002
Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase*
The RING finger of BRCA1 confers ubiquitin ligase activity that is markedly enhanced when complexed with another RING-containing… 
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