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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 single mouseExpand
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Mice lacking brain-derived neurotrophic factor develop with sensory deficits
DURING vertebrate development, neuronal survival depends on target-derived neurotrophic factors1,2. Brain-derived neurotrophic factor3 (BDNF), a member of the neurotrophin family, can prevent theExpand
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Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
Recent studies have indicated that exogenously administered neurotrophins produce antidepressant-like behavioral effects. We have here investigated the role of endogenous brain-derived neurotrophicExpand
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Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus
Antidepressants increase proliferation of neuronal progenitor cells and expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. We investigated the role of BDNF signaling inExpand
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Specification and connectivity of neuronal subtypes in the sensory lineage
During the development of the nervous system, many different types of neuron are produced. As well as forming the correct type of neuron, each must also establish precise connections. Recent findingsExpand
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Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
Neurotrophin-3-deficient (NT-3-deficient) mice were generated by gene targeting. Mutant mice displayed severe movement defects of the limbs, and most died shortly after birth. Substantial portions ofExpand
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Molecular Architecture of the Mouse Nervous System
Summary The mammalian nervous system executes complex behaviors controlled by specialized, precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a million singleExpand
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Complementary roles of BDNF and NT-3 in vestibular and auditory development
The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survivalExpand
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Sensory but not motor neuron deficits in mice lacking NT4 and BDNF
NEUROTROPHINS play important roles in neuronal survival during vertebrate development1–3. Neurotrophin-4 (NT4), alone or in combination with brain-derived neurotrophic factor (BDNF), has beenExpand
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Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development
In situ hybridization analysis of cells expressing messenger RNAs (mRNAs) for the neurotrophins nerve growth factor (NGF), brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 (NT‐3) and theirExpand
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