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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
The results suggest that itching during inflammatory skin diseases such as atopic dermatitis is linked to a distinct itch-generating type, and demonstrate single-cell RNA-seq as an effective strategy for dissecting sensory responsive cells into distinct neuronal types.
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
It is shown that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion, and that BDNF is required for the survival and target innervation of particular neuronal populations.
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus
It is observed that chronic treatment with imipramine or fluoxetine produced a temporally similar increase in both BrdU-positive and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end-labeled neurons in the dentate gyrus, indicating that these drugs simultaneously increase both neurogenesis and neuronal elimination.
Specification and connectivity of neuronal subtypes in the sensory lineage
This review examines how neuronal diversity is created in the PNS and describes proteins that help to direct the diversity of neuronal subtypes, cell survival, axonal growth and the establishment of central patterns of modality-specific connections.
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
The data suggest that antidepressants acutely increase trkB signaling in a BDNF-dependent manner in cerebral cortex and that this signaling is required for the behavioral effects typical of antidepressant drugs.
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
The dynamics of oligodendrocyte differentiation and maturation are revealed, uncoupling them at a transcriptional level and highlighting oligodendedrocytes heterogeneity in the central nervous system.
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF
NT4 is required during development for the survival of some peripheral sensory neurons but not sympathetic or motor neurons, and in mice lacking both NT4 and BDNF, facial motor neurons remained unaffected, whereas the loss of sensory neurons was more severe than with either mutation alone.