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Double Strand Break Repair

Known as: Double-Strand Break Repair 
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the… Expand
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Review
2017
Review
2017
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large… Expand
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Review
2017
Review
2017
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome… Expand
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Review
2017
Review
2017
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and chemicals or result from faulty DNA metabolic… Expand
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Review
2017
Review
2017
For decades, it has been speculated that specific loci on eukaryotic chromosomes are inherently susceptible to breakage. The… Expand
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Review
2017
Review
2017
Targeted genome editing has become a powerful genetic tool for studying gene function or for modifying genomes by correcting… Expand
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Highly Cited
2005
Highly Cited
2005
BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes… Expand
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Highly Cited
2003
Highly Cited
2003
DNA double-strand breaks (DSBs) are generally accepted to be the most biologically significant lesion by which ionizing radiation… Expand
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Highly Cited
2003
Highly Cited
2003
Little is known about the quantitative contributions of nonhomologous end joining (NHEJ) and homologous recombination (HR) to DNA… Expand
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Highly Cited
1998
Highly Cited
1998
Eukaryotic cells repair DNA double-strand breaks (DSBs) by at least two pathways, homologous recombination (HR) and non… Expand
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