Double Strand Break Repair

Known as: Double-Strand Break Repair 
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
05010015019752017

Papers overview

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Review
2015
Review
2015
Among DNA damages, double-strand breaks (DSBs) are one of the most harmful lesions to a cell. Failure in DSB repair could lead to… (More)
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Highly Cited
2011
Highly Cited
2011
Breast cancer suppressor BRCA2 is critical for maintenance of genomic integrity and resistance to agents that damage DNA or… (More)
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Highly Cited
2010
Highly Cited
2010
DNA double-strand breaks (DSBs) represent an important radiation-induced lesion and impaired DSB repair provides the best… (More)
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Highly Cited
2005
Highly Cited
2005
BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes… (More)
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Highly Cited
2004
Highly Cited
2004
The pathway determining malignant cellular transformation, which depends upon mutation of the BRCA1 tumor suppressor gene, is… (More)
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Highly Cited
2003
Highly Cited
2003
Little is known about the quantitative contributions of nonhomologous end joining (NHEJ) and homologous recombination (HR) to DNA… (More)
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Highly Cited
2003
Highly Cited
2003
DNA double-strand breaks (DSBs) are generally accepted to be the most biologically significant lesion by which ionizing radiation… (More)
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Highly Cited
2001
Highly Cited
2001
The Ku heterodimer (Ku70 and Ku80 subunits) contributes to genomic integrity through its ability to bind DNA double-strand breaks… (More)
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Highly Cited
2000
Highly Cited
2000
In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous and non-homologous mechanisms. By… (More)
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Highly Cited
1998
Highly Cited
1998
Nijmegen breakage syndrome (NBS) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth… (More)
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