BRCA1 gene

Known as: BRCC1, BRCA1 Genes, BRCA1 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to breast and ovarian cancer. BRCA1-mutated… (More)
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Highly Cited
2009
Highly Cited
2009
Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Genetic counseling is now routinely offered to individuals at high risk of carrying a BRCA1 or BRCA2 mutation. Risk… (More)
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Highly Cited
2007
Highly Cited
2007
The BRCT repeats of the breast and ovarian cancer predisposition protein BRCA1 are essential for tumor suppression… (More)
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Highly Cited
2003
Highly Cited
2003
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Data concerning the efficacy of bilateral prophylactic oophorectomy for reducing the risk of gynecologic cancer in… (More)
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Highly Cited
2001
Highly Cited
2001
A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in Ontario, Canada, during 1995-96 was… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have… (More)
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