BRCA1 gene

Known as: BRCC1, BRCA1 Genes, BRCA1 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the… (More)
National Institutes of Health

Related topics

Related topics

21 relations
BRCA1 Ag:PrThr:Pt:Tiss:Ord:Immune stainBRCA1 Gene MutationBRCA1 ProteinBRCA1 Syndrome
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Narrower (1)

BRCA1 wt Allele

Broader (1)

brca gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
Germ-line mutations in breast cancer 1, early onset (BRCA1) result in predisposition to breast and ovarian cancer. BRCA1-mutated… (More)
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Highly Cited
2009
Highly Cited
2009
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are… (More)
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Highly Cited
2007
Highly Cited
2007
Meta-analysis of BRCA1 and BRCA2 penetrance.
PURPOSE Genetic counseling is now routinely offered to individuals at high risk of carrying a BRCA1 or BRCA2 mutation. Risk… (More)
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Highly Cited
2007
Highly Cited
2007
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
The BRCT repeats of the breast and ovarian cancer predisposition protein BRCA1 are essential for tumor suppression… (More)
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Highly Cited
2003
Highly Cited
2003
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… (More)
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Highly Cited
2002
Highly Cited
2002
Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations.
BACKGROUND Data concerning the efficacy of bilateral prophylactic oophorectomy for reducing the risk of gynecologic cancer in… (More)
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Highly Cited
2001
Highly Cited
2001
Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer.
A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in Ontario, Canada, during 1995-96 was… (More)
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Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… (More)
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Highly Cited
1999
Highly Cited
1999
Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.
BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with… (More)
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Highly Cited
1997
Highly Cited
1997
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have… (More)
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