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BRCA1 gene
Known as:
BRCC1
, BRCA1 Genes
, BRCA1
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A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the…
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National Institutes of Health
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Related topics
Related topics
21 relations
BRCA1 Ag:PrThr:Pt:Tiss:Ord:Immune stain
BRCA1 Gene Mutation
BRCA1 Protein
BRCA1 Syndrome
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Narrower (1)
BRCA1 wt Allele
Broader (1)
brca gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
M. Audeh
,
J. Carmichael
,
+12 authors
A. Tutt
The Lancet
2010
Corpus ID: 34142559
Highly Cited
2009
Highly Cited
2009
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
P. Fong
,
D. Boss
,
+12 authors
J. D. de Bono
The New England journal of medicine
2009
Corpus ID: 10051747
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal…
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Highly Cited
2003
Highly Cited
2003
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
A. Antoniou
,
P. Pharoah
,
+30 authors
D. Easton
American journal of human genetics
2003
Corpus ID: 34521425
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is…
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Highly Cited
2002
Highly Cited
2002
Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations.
T. Rebbeck
,
H. Lynch
,
+9 authors
B. Weber
The New England journal of medicine
2002
Corpus ID: 39377533
BACKGROUND Data concerning the efficacy of bilateral prophylactic oophorectomy for reducing the risk of gynecologic cancer in…
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Highly Cited
2001
Highly Cited
2001
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers.
L. Hartmann
,
T. Sellers
,
+12 authors
R. Jenkins
Journal of the National Cancer Institute
2001
Corpus ID: 24688392
BACKGROUND In women with a family history of breast cancer, bilateral prophylactic mastectomy is associated with a decreased risk…
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Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
M. Esteller
,
J. Silva
,
+11 authors
J. Herman
Journal of the National Cancer Institute
2000
Corpus ID: 25878691
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However…
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Highly Cited
1999
Highly Cited
1999
Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.
J. Peto
,
N. Collins
,
+7 authors
M. Stratton
Journal of the National Cancer Institute
1999
Corpus ID: 17412220
BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with…
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Highly Cited
1998
Highly Cited
1998
Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.
D. Ford
,
D. Easton
,
+22 authors
M. Zelada-Hedman
American journal of human genetics
1998
Corpus ID: 34902111
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families…
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Highly Cited
1997
Highly Cited
1997
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
J. Struewing
,
P. Hartge
,
+6 authors
M. Tucker
The New England journal of medicine
1997
Corpus ID: 7928871
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have…
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Highly Cited
1995
Highly Cited
1995
Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.
D. Ford
,
D. Easton
,
J. Peto
American journal of human genetics
1995
Corpus ID: 34989280
The majority of multiple-case families that segregate both breast and ovarian cancer in a dominant fashion are due to mutations…
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