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BRCA1 gene

Known as: BRCC1, BRCA1 Genes, BRCA1 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the… 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal… 
Highly Cited
2003
Highly Cited
2003
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… 
Highly Cited
2002
Highly Cited
2002
BACKGROUND Data concerning the efficacy of bilateral prophylactic oophorectomy for reducing the risk of gynecologic cancer in… 
Highly Cited
2001
Highly Cited
2001
BACKGROUND In women with a family history of breast cancer, bilateral prophylactic mastectomy is associated with a decreased risk… 
Highly Cited
2000
Highly Cited
2000
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… 
Highly Cited
1999
Highly Cited
1999
BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with… 
Highly Cited
1998
Highly Cited
1998
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families… 
Highly Cited
1997
Highly Cited
1997
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have… 
Highly Cited
1995
Highly Cited
1995
The majority of multiple-case families that segregate both breast and ovarian cancer in a dominant fashion are due to mutations…