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BRCA1 gene

Known as: BRCC1, BRCA1 Genes, BRCA1 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the… Expand
National Institutes of Health

Related topics

Related topics

21 relations
BRCA1 Ag:PrThr:Pt:Tiss:Ord:Immune stainBRCA1 Gene MutationBRCA1 ProteinBRCA1 Syndrome
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Narrower (1)

BRCA1 wt Allele

Broader (1)

brca gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Differential Response to Olaparib Treatment Among Men with Metastatic Castration-resistant Prostate Cancer Harboring BRCA1 or BRCA2 Versus ATM Mutations.
BACKGROUND Poly ADP-ribose polymerase (PARP) inhibitors, such as olaparib, are being explored as a treatment option for… Expand
Is this relevant?
Review
2018
Review
2018
Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer.
Germ-line and somatic mutations in genes that promote homology-directed repair (HDR), especially BRCA1 and BRCA2, are frequently… Expand
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal… Expand
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Is this relevant?
Highly Cited
2003
Highly Cited
2003
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers.
BACKGROUND In women with a family history of breast cancer, bilateral prophylactic mastectomy is associated with a decreased risk… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer.
A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in Ontario, Canada, during 1995-96 was… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… Expand
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Highly Cited
1999
Highly Cited
1999
Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.
BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with… Expand
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Is this relevant?
Highly Cited
1997
Highly Cited
1997
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.
The majority of multiple-case families that segregate both breast and ovarian cancer in a dominant fashion are due to mutations… Expand
Is this relevant?
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