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BRCA1 gene

Known as: BRCC1, BRCA1 Genes, BRCA1 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the… 
National Institutes of Health

Related topics

Related topics

21 relations
BRCA1 Ag:PrThr:Pt:Tiss:Ord:Immune stainBRCA1 Gene MutationBRCA1 ProteinBRCA1 Syndrome

Narrower (1)

BRCA1 wt Allele

Broader (1)

brca gene

Papers overview

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Highly Cited
2009
Highly Cited
2009
Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients.
A HIC1-SIRT1-p53 circular loop in which hypermethylation in cancer 1 (HIC1) represses the transcription of SIRT1 that… 
Highly Cited
2002
Highly Cited
2002
BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets
ABSTRACT The pathway leading to BRCA1-dependent tumor suppression is not yet clear but appears to involve activities in DNA… 
Highly Cited
2002
Highly Cited
2002
A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining
Heterozygosity for mutations in the BRCA1 gene in humans confers high risk for developing breast cancer, but a biochemical basis… 
Highly Cited
2001
Highly Cited
2001
An Isoform of the Coactivator AIB1 That Increases Hormone and Growth Factor Sensitivity Is Overexpressed in Breast Cancer*
The AIB1 (amplified in breast cancer 1) protein is a coactivator that potentiates the transcriptional activity of nuclear hormone… 
Highly Cited
2001
Highly Cited
2001
Large regional differences in the frequency of distinct BRCA1/BRCA2 mutations in 517 Dutch breast and/or ovarian cancer families.
Highly Cited
2000
Highly Cited
2000
Testing for erbB-2 by immunohistochemistry in breast cancer.
The success of recent clinical trials using Herceptin (trastuzumab, a humanized anti–erbB-2 antibody) as therapy for patients… 
Highly Cited
1999
Highly Cited
1999
Clinicopathologic analysis of BRCA1‐ or BRCA2‐associated hereditary breast carcinoma in Japanese women
The purpose of this investigation was to elucidate the clinicopathologic characteristics of BRCA1‐ and BRCA2‐associated… 
Highly Cited
1998
Highly Cited
1998
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region
Germ-line alterations of BRCA1 are responsible for about 50% of familial breast cancers. Although its biological function(s) has… 
Highly Cited
1996
Highly Cited
1996
A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.
We have analyzed 20 breast-ovarian cancer families, the majority of which show positive evidence of linkage to chromosome 17q12… 
Highly Cited
1996
Highly Cited
1996
Human, canine and murine BRCA1 genes: sequence comparison among species.
Five to ten percent of breast cancer in the western world may be attributed to the inheritance of highly penetrant mutations in… 
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