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BRCA1 gene

Known as: BRCC1, BRCA1 Genes, BRCA1 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the… 
National Institutes of Health

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Related topics

21 relations
BRCA1 Ag:PrThr:Pt:Tiss:Ord:Immune stainBRCA1 Gene MutationBRCA1 ProteinBRCA1 Syndrome
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BRCA1 wt Allele

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brca gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
Highly Cited
2009
Highly Cited
2009
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal… 
Highly Cited
2003
Highly Cited
2003
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… 
Highly Cited
2002
Highly Cited
2002
Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations.
BACKGROUND Data concerning the efficacy of bilateral prophylactic oophorectomy for reducing the risk of gynecologic cancer in… 
Highly Cited
2001
Highly Cited
2001
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers.
BACKGROUND In women with a family history of breast cancer, bilateral prophylactic mastectomy is associated with a decreased risk… 
Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
BACKGROUND Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However… 
Highly Cited
1999
Highly Cited
1999
Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.
BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with… 
Highly Cited
1998
Highly Cited
1998
Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families… 
Highly Cited
1997
Highly Cited
1997
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have… 
Highly Cited
1995
Highly Cited
1995
Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.
The majority of multiple-case families that segregate both breast and ovarian cancer in a dominant fashion are due to mutations… 
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