E. Ostrander

Publications504
h-index96
Citations33,586
Highly Influential Citations1,533
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Genome sequence, comparative analysis and haplotype structure of the domestic dog
TLDR
A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes.
REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants.
Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps
TLDR
It is found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.
Genetic Structure of the Purebred Domestic Dog
TLDR
This work identified four genetic clusters, which predominantly contained breeds with similar geographic origin, morphology, or role in human activities, which will aid studies of the genetics of phenotypic breed differences.
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
TLDR
It is shown that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data.
Genome Sequencing Highlights the Dynamic Early History of Dogs
TLDR
It is found that none of the extant wolf lineages from putative domestication centers is more closely related to dogs, and, instead, the sampled wolves form a sister monophyletic clade, suggesting that a re-evaluation of past hypotheses regarding dog origins is necessary.
Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci.
TLDR
It is demonstrated that wolves and coyotes do not show a pattern of genetic differentiation by distance, and gray wolves show significant subdivision that may be either due to drift in past Ice Age refugia populations or a result of other causes.
Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes.
TLDR
The inclusion of 320 dog genes into this integrated map enhances existing comparative mapping data between human and dog, and the 1000 mapped microsatellite markers constitute an invaluable tool with which to perform genome scanning studies on pedigrees of interest.
Extensive and breed-specific linkage disequilibrium in Canis familiaris.
TLDR
Low haplotype diversity within regions of high LD, with 80% of chromosomes in a breed carrying two to four haplotypes, as well as a high degree of haplotype sharing among breeds, are reported.
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids.
TLDR
It is found that these enigmatic canids are highly admixed varieties derived from gray wolves and coyotes, respectively, and divergent genomic history suggests that they do not have a shared recent ancestry as proposed by previous researchers.
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