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Genome sequence, comparative analysis and haplotype structure of the domestic dog
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular… Expand
REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants.
- N. Ioannidis, J. Rothstein, +38 authors W. Sieh
- Biology, Medicine
- American journal of human genetics
- 6 October 2016
The vast majority of coding variants are rare, and assessment of the contribution of rare variants to complex traits is hampered by low statistical power and limited functional data. Improved methods… Expand
Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps
The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution.… Expand
Genetic Structure of the Purebred Domestic Dog
We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for ∼30% of genetic variation. Microsatellite genotypes… Expand
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
Advances in genome technology have facilitated a new understanding of the historical and genetic processes crucial to rapid phenotypic evolution under domestication. To understand the process of dog… Expand
Genome Sequencing Highlights the Dynamic Early History of Dogs
To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the… Expand
Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci.
- M. S. Roy, E. Geffen, D. Smith, E. Ostrander, R. Wayne
- Medicine, Biology
- Molecular biology and evolution
- 1 July 1994
Genetic divergence and gene flow among closely related populations are difficult to measure because mutation rates of most nuclear loci are so low that new mutations have not had sufficient time to… Expand
Extensive and breed-specific linkage disequilibrium in Canis familiaris.
The 156 breeds of registered dogs in the United States offer a unique opportunity to map genes important in disease susceptibility, morphology, and behavior. Linkage disequilibrium (LD) is of current… Expand
Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes.
We present here the first fully integrated, comprehensive map of the canine genome, incorporating detailed cytogenetic, radiation hybrid (RH), and meiotic information. We have mapped a collection of… Expand
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids.
High-throughput genotyping technologies developed for model species can potentially increase the resolution of demographic history and ancestry in wild relatives. We use a SNP genotyping microarray… Expand