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Genome sequence, comparative analysis and haplotype structure of the domestic dog
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particularExpand
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REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants.
The vast majority of coding variants are rare, and assessment of the contribution of rare variants to complex traits is hampered by low statistical power and limited functional data. Improved methodsExpand
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Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps
The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution.Expand
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Genetic Structure of the Purebred Domestic Dog
We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for ∼30% of genetic variation. Microsatellite genotypesExpand
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Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
Advances in genome technology have facilitated a new understanding of the historical and genetic processes crucial to rapid phenotypic evolution under domestication. To understand the process of dogExpand
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Genome Sequencing Highlights the Dynamic Early History of Dogs
To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of theExpand
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Patterns of differentiation and hybridization in North American wolflike canids, revealed by analysis of microsatellite loci.
Genetic divergence and gene flow among closely related populations are difficult to measure because mutation rates of most nuclear loci are so low that new mutations have not had sufficient time toExpand
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Extensive and breed-specific linkage disequilibrium in Canis familiaris.
The 156 breeds of registered dogs in the United States offer a unique opportunity to map genes important in disease susceptibility, morphology, and behavior. Linkage disequilibrium (LD) is of currentExpand
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Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes.
We present here the first fully integrated, comprehensive map of the canine genome, incorporating detailed cytogenetic, radiation hybrid (RH), and meiotic information. We have mapped a collection ofExpand
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A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids.
High-throughput genotyping technologies developed for model species can potentially increase the resolution of demographic history and ancestry in wild relatives. We use a SNP genotyping microarrayExpand
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