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BRCA1 wt Allele
Known as:
BRCC1
, BRCA1
, FANCS
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Human BRCA1 wild-type allele is located within 17q21 and is approximately 81 kb in length. This allele, which encodes breast cancer type 1…
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National Institutes of Health
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Related topics
Related topics
20 relations
17q21
ATM Signaling Pathway
BARD1 Pathway
BRCA1 Protein
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Broader (1)
BRCA1 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Impact of RING and BRCT Domain Mutations on BRCA1 Protein Stability, Localization and Recruitment to DNA Damage
A. Nelson
,
J. Holt
Radiation Research
2010
Corpus ID: 25761513
Abstract Mutations within the tumor suppressor BRCA1 cause the majority of hereditary breast and ovarian cancers. The BRCA1…
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2008
2008
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
S. Kyle
,
Huw D. Thomas
,
J. Mitchell
,
N. Curtin
British Journal of Radiology
2008
Corpus ID: 5092543
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates DNA single-strand break-base excision repair to maintain genomic stability…
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2005
2005
Patients with an unclassified genetic variant in the BRCA1 or BRCA2 genes show different clinical features from those with a mutation.
E. Gomez-Garcia
,
Ton A W Ambergen
,
M. Blok
,
A. van den Wijngaard
Journal of Clinical Oncology
2005
Corpus ID: 22607127
PURPOSE To obtain and compare the probabilities of finding a mutation in the BRCA1 or BRCA2 genes, the clinical features, and the…
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2001
2001
BRCA1 at a branch point
J. Parvin
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 31336234
The breast- and ovarian-specific tumor suppressor protein, BRCA1, has been implicated in regulating the nuclear processes of…
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Highly Cited
2000
Highly Cited
2000
VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells.
Hongtao Zhang
,
Qiang Wang
,
K. Kajino
,
Mark I Greene
DNA and Cell Biology
2000
Corpus ID: 23597614
BRCA1, a breast/ovarian cancer susceptibility gene, undergoes mutations in as many as 50% of familial breast tumors. Recent…
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2000
2000
Genetic alterations of the WT1 gene in papillary serous carcinoma of the peritoneum.
J. Schorge
,
Y. Miller
,
+4 authors
S. Mok
Gynecologic Oncology
2000
Corpus ID: 2233169
OBJECTIVE The Wilms' tumor (WT1) gene product is consistently detectable in both normal ovarian germinal epithelium and human…
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Highly Cited
1999
Highly Cited
1999
BRCA1 expression levels predict distant metastasis of sporadic breast cancers
L. Seery
,
J. Knowlden
,
+4 authors
R. Nicholson
International Journal of Cancer
1999
Corpus ID: 28665125
The role of BRCA1 in progression of sporadic breast cancers has to date been equivocal, although preliminary studies on small…
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Highly Cited
1997
Highly Cited
1997
Patterns of allelic loss on chromosome 17 in sporadic breast carcinomas detected by fluorescent‐labeled microsatellite analysis
D. Niederacher
,
F. Picard
,
Claudia van Roeyen
,
H. An
,
H. Bender
,
M. W. Beckmann
Genes, Chromosomes and Cancer
1997
Corpus ID: 23265296
Loss of heterozygosity (LOH) on chromosome 17 is a frequent genetic alteration in breast cancer. To assess whether the location…
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Review
1996
Review
1996
THe genetics of familial breast cancer.
L. Cannon-Albright
,
M. Skolnick
Seminars in Oncology
1996
Corpus ID: 19832507
Because studies of breast cancer patients and their relatives provide statistical evidence for involvement of autosomal dominant…
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Highly Cited
1993
Highly Cited
1993
Genetic analysis of the BRCA1 region in a large breast/ovarian family: refinement of the minimal region containing BRCA1.
D. Kelsell
,
D. Black
,
D. Bishop
,
N. Spurr
Human Molecular Genetics
1993
Corpus ID: 28535987
We have analyzed a single multi-affected breast/ovarian cancer pedigree (BOV3) and have shown consistent inheritance of markers…
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