BRCA1 wt Allele

Known as: BRCC1, BRCA1, FANCS 
Human BRCA1 wild-type allele is located within 17q21 and is approximately 81 kb in length. This allele, which encodes breast cancer type 1… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis. Paradoxically, BRCA1… (More)
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Highly Cited
2009
Highly Cited
2009
BRCA1 and BRCA2 are often mutated in familial breast and ovarian cancer. Both tumor suppressors play key roles in the DNA-damage… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic… (More)
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Highly Cited
2004
Highly Cited
2004
Aurora-A/BTAK/STK15 localizes to the centrosome in the G(2)-M phase, and its kinase activity regulates the G(2) to M transition… (More)
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Highly Cited
2003
Highly Cited
2003
We have evaluated the role played by BRCA1 in mediating the phenotypic response to a range of chemotherapeutic agents commonly… (More)
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Highly Cited
2002
Highly Cited
2002
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain—a motif that is found in many proteins that… (More)
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Review
2001
Review
2001
In mammalian cells, the repair of DNA double-strand breaks (DSBs) occurs by both homologous and non-homologous mechanisms… (More)
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Highly Cited
1999
Highly Cited
1999
BRCA1 is a nuclear phosphoprotein that has been classified as a tumor suppressor based on the fact that women carrying a mutated… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Hereditary breast cancer has been associated with mutations in the BRCA1 and BRCA2 genes and has a natural history… (More)
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Highly Cited
1996
Highly Cited
1996
OBJECTIVES To identify predictors of utilization of breast-ovarian cancer susceptibility (BRCA1 gene) testing and to evaluate… (More)
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