Skip to search formSkip to main contentSkip to account menu

BRCA1 wt Allele

Known as: BRCC1, BRCA1, FANCS 
Human BRCA1 wild-type allele is located within 17q21 and is approximately 81 kb in length. This allele, which encodes breast cancer type 1… 
National Institutes of Health

Related topics

Related topics

20 relations
17q21ATM Signaling PathwayBARD1 PathwayBRCA1 Protein

Broader (1)

BRCA1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Impact of RING and BRCT Domain Mutations on BRCA1 Protein Stability, Localization and Recruitment to DNA Damage
Abstract Mutations within the tumor suppressor BRCA1 cause the majority of hereditary breast and ovarian cancers. The BRCA1… 
2008
2008
Exploiting the Achilles heel of cancer: the therapeutic potential of poly(ADP-ribose) polymerase inhibitors in BRCA2-defective cancer.
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates DNA single-strand break-base excision repair to maintain genomic stability… 
2005
2005
Patients with an unclassified genetic variant in the BRCA1 or BRCA2 genes show different clinical features from those with a mutation.
PURPOSE To obtain and compare the probabilities of finding a mutation in the BRCA1 or BRCA2 genes, the clinical features, and the… 
2001
2001
BRCA1 at a branch point
The breast- and ovarian-specific tumor suppressor protein, BRCA1, has been implicated in regulating the nuclear processes of… 
Highly Cited
2000
Highly Cited
2000
VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells.
BRCA1, a breast/ovarian cancer susceptibility gene, undergoes mutations in as many as 50% of familial breast tumors. Recent… 
2000
2000
Genetic alterations of the WT1 gene in papillary serous carcinoma of the peritoneum.
OBJECTIVE The Wilms' tumor (WT1) gene product is consistently detectable in both normal ovarian germinal epithelium and human… 
Highly Cited
1999
Highly Cited
1999
BRCA1 expression levels predict distant metastasis of sporadic breast cancers
The role of BRCA1 in progression of sporadic breast cancers has to date been equivocal, although preliminary studies on small… 
Highly Cited
1997
Highly Cited
1997
Patterns of allelic loss on chromosome 17 in sporadic breast carcinomas detected by fluorescent‐labeled microsatellite analysis
Loss of heterozygosity (LOH) on chromosome 17 is a frequent genetic alteration in breast cancer. To assess whether the location… 
Review
1996
Review
1996
THe genetics of familial breast cancer.
Because studies of breast cancer patients and their relatives provide statistical evidence for involvement of autosomal dominant… 
Highly Cited
1993
Highly Cited
1993
Genetic analysis of the BRCA1 region in a large breast/ovarian family: refinement of the minimal region containing BRCA1.
We have analyzed a single multi-affected breast/ovarian cancer pedigree (BOV3) and have shown consistent inheritance of markers… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)