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BRCA1 wt Allele

Known as: BRCC1, BRCA1, FANCS 
Human BRCA1 wild-type allele is located within 17q21 and is approximately 81 kb in length. This allele, which encodes breast cancer type 1… 
National Institutes of Health

Related topics

Related topics

20 relations
17q21ATM Signaling PathwayBARD1 PathwayBRCA1 Protein

Broader (1)

BRCA1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Background: Whether oophorectomy reduces breast cancer risk among BRCA mutation carriers is a matter of debate. We undertook a… 
Highly Cited
2014
Highly Cited
2014
PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.
UNLABELLED BRCA1 promotes homologous recombination-mediated DNA repair (HRR). However, HRR must be tightly regulated to prevent… 
Highly Cited
2011
Highly Cited
2011
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose… 
Review
2008
Review
2008
DNA repair deficiency as a therapeutic target in cancer.
Highly Cited
2004
Highly Cited
2004
Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences
ABSTRACT Repair of chromosomal breaks is essential for cellular viability, but misrepair generates mutations and gross… 
Highly Cited
2004
Highly Cited
2004
Breast Cancer Risk and the DNA Double-Strand Break End-Joining Capacity of Nonhomologous End-Joining Genes Are Affected by BRCA1
A tumorigenic role of the nonhomologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks (DSBs) has been… 
Highly Cited
2000
Highly Cited
2000
Anticipated versus actual emotional reactions to disclosure of results of genetic tests for cancer susceptibility: findings from p53 and BRCA1 testing programs.
PURPOSE We examined the ability of individuals undergoing genetic testing for cancer susceptibility in two structured research… 
Highly Cited
1999
Highly Cited
1999
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts… 
Highly Cited
1997
Highly Cited
1997
A descriptive study of BRCA1 testing and reactions to disclosure of test results
The identification of the BRCA1 gene is a powerful tool for predicting a patient's lifetime risk for carcinoma of the breast and… 
Highly Cited
1996
Highly Cited
1996
Cancer mortality in relatives of women with breast cancer: The OPCS study
Mortality from cancer and other causes in male and female first‐degree relatives of women with breast cancer diagnosed before age… 
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