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BRCA1 Gene Mutation

Known as: BRCA1 Mutation, Mutation of the BRCA1 Gene 
A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA1 gene. Single nucleotide substitutions and small… Expand
National Institutes of Health

Papers overview

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2013
2013
The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews… Expand
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2008
2008
Breast cancer rates and median age of onset differ between Western Europe and North Africa. In Western populations, 5 to 10 % of… Expand
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2005
2005
The authors report a prospective study comparing magnetic resonance imaging (MRI) with mammography for screening in women having… Expand
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2004
2004
Mutations in breast cancer susceptibility genes, BRCA1 and BRCA2 account for more than 80% of hereditary breast and ovarian… Expand
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2003
2003
Sixty high-risk breast and/or ovarian cancer families from North-Eastern Poland were screened for germline mutations in BRCA1… Expand
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2000
2000
BRCA1 mutations have been identified in breast and ovarian cancer families from diverse ethnic backgrounds. We studied 17… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Breast carcinomas occurring in carriers of BRCA1 gene mutations may have a distinctly different pathway of molecular… Expand
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1999
1999
Germ-line mutations of the BRCA1 gene account for approximately half of the cases of hereditary breast/ovarian cancers. We have… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND To define the incidence of BRCA1 mutations among patients seen in clinics that evaluate the risk of breast cancer, we… Expand
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1997
1997
A predominant mutation within the BRCA1 predisposition gene, 185delAG, has been detected in about 1 % of the Ashkenazi population… Expand
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