BRCA1 protein, human

Known as: EC6.3.2.-, RING Finger Protein 53, BRCA1 
Breast cancer type 1 susceptibility protein (1863 aa, ~208 kDa) is encoded by the human BRCA1 gene. This protein plays a role in both the maintenance… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in… (More)
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Highly Cited
2009
Highly Cited
2009
Mutations in BRCA1 are associated with a high risk of breast and ovarian cancer. BRCA1 participates in the DNA damage response… (More)
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2009
2009
Previous studies have shown that the breast cancer suppressor BRCA1 stimulates antioxidant gene expression and protects cells… (More)
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Highly Cited
2005
Highly Cited
2005
The breast- and ovarian-specific tumor suppressor BRCA1, when associated with BARD1, is an ubiquitin ligase. We have shown here… (More)
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Highly Cited
2002
Highly Cited
2002
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain—a motif that is found in many proteins that… (More)
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2002
2002
The p53 and BRCA1 tumor suppressors are involved in repair processes and may cooperate to transactivate certain genes, including… (More)
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Highly Cited
2001
Highly Cited
2001
The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions… (More)
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Highly Cited
2000
Highly Cited
2000
The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of… (More)
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Highly Cited
1998
Highly Cited
1998
Germ-line alterations of BRCA1 are responsible for about 50% of familial breast cancers. Although its biological function(s) has… (More)
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Highly Cited
1997
Highly Cited
1997
We have characterized the BRCA1 gene product by using four polyclonal antibodies raised against peptides from four different… (More)
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