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BRCA1 protein, human

Known as: EC6.3.2.-, RING Finger Protein 53, BRCA1 
Breast cancer type 1 susceptibility protein (1863 aa, ~208 kDa) is encoded by the human BRCA1 gene. This protein plays a role in both the maintenance… 
National Institutes of Health

Related topics

Related topics

27 relations
ATM Signaling PathwayBARD1 PathwayBRCA1 geneBRCA1 wt Allele

Broader (1)

BRCA1 Protein

Papers overview

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Highly Cited
2007
Highly Cited
2007
A role of estrogen/ERα signaling in BRCA1-associated tissue-specific tumor formation
Estrogen and its receptor alpha (ERα) have been implicated in the tissue-specific tumorigenesis associated with BRCA1 mutations… 
Highly Cited
2006
Highly Cited
2006
BRCA1 Affects Lipid Synthesis through Its Interaction with Acetyl-CoA Carboxylase*
Germ line alterations in BRCA1 (breast cancer susceptibility gene 1) are associated with an increased susceptibility to breast… 
Highly Cited
2006
Highly Cited
2006
BRCA1 DNA-binding activity is stimulated by BARD1.
The breast- and ovarian-specific tumor suppressor BRCA1 has been implicated in numerous cellular processes, including… 
Highly Cited
2005
Highly Cited
2005
BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II*
The breast- and ovarian-specific tumor suppressor BRCA1, when associated with BARD1, is an ubiquitin ligase. We have shown here… 
Highly Cited
2003
Highly Cited
2003
Functional and Physical Interactions between BRCA1 and p53 in Transcriptional Regulation of the IGF-IR Gene
The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of the IGFs, and is critical for normal… 
Highly Cited
2000
Highly Cited
2000
Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer.
The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of… 
Review
2000
Review
2000
BRCA1: exploring the links to transcription.
Highly Cited
1999
Highly Cited
1999
Heregulin Induces Phosphorylation of BRCA1 through Phosphatidylinositol 3-Kinase/AKT in Breast Cancer Cells*
The breast cancer susceptibility geneBRCA1 encodes a nuclear phosphoprotein that acts as a tumor suppressor. Phosphorylation of… 
Highly Cited
1998
Highly Cited
1998
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region
Germ-line alterations of BRCA1 are responsible for about 50% of familial breast cancers. Although its biological function(s) has… 
Highly Cited
1997
Highly Cited
1997
BRCA1 is a cell cycle-regulated nuclear phosphoprotein.
We have characterized the BRCA1 gene product by using four polyclonal antibodies raised against peptides from four different… 
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