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BRCA1 protein, human

Known as: EC6.3.2.-, RING Finger Protein 53, BRCA1 
Breast cancer type 1 susceptibility protein (1863 aa, ~208 kDa) is encoded by the human BRCA1 gene. This protein plays a role in both the maintenance… 
National Institutes of Health

Related topics

Related topics

27 relations
ATM Signaling PathwayBARD1 PathwayBRCA1 geneBRCA1 wt Allele

Broader (1)

BRCA1 Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
BRCA1-Dependent Translational Regulation in Breast Cancer Cells
BRCA1 (Breast Cancer 1) has been implicated in a number of cellular processes, including transcription regulation, DNA damage… 
2010
2010
PI 3 Kinase Related Kinases-Independent Proteolysis of BRCA1 Regulates Rad51 Recruitment during Genotoxic Stress in Human Cells
Background The function of BRCA1 in response to ionizing radiation, which directly generates DNA double strand breaks, has been… 
2009
2009
Association of loss of BRCA1 expression with centrosome aberration in human breast cancer
PurposeCentrosome aberration in number and/or size is reportedly often observed in human breast cancer. The aim of this study was… 
Highly Cited
2007
Highly Cited
2007
Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.
BRCA1/2 mutations predispose to early onset breast and ovarian cancers. The phenotypic expression of mutant alleles, however, is… 
2006
2006
CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia
Abstract Gibson, S. L., Bindra, R. S. and Glazer, P. M. CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia. Radiat. Res. 166, 646… 
2006
2006
The BRCA1 COOH-terminal Region Acts as an RNA Polymerase II Carboxyl-terminal Domain Kinase Inhibitor That Modulates p21WAF1/CIP1 Expression*
BRCA1 is involved both in positive and negative regulation of gene activity as well as in numerous other processes, such as DNA… 
Review
2001
Review
2001
Role played by BRCA1 in regulating the cellular response to stress.
BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor gene that is mutated in the germline of women with a genetic… 
Review
2000
Review
2000
BRCA1: exploring the links to transcription.
Highly Cited
1998
Highly Cited
1998
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region
Germ-line alterations of BRCA1 are responsible for about 50% of familial breast cancers. Although its biological function(s) has… 
1998
1998
Identification of a BRCA1-associated kinase with potential biological relevance
A biochemical approach was used to identify proteins which interact with human BRCA1. Through this work, a kinase activity which… 
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