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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
When oxygen is abundant, quiescent cells efficiently extract energy from glucose primarily by oxidative phosphorylation, whereas under the same conditions tumour cells consume glucose more avidly,… Expand
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease
Most eukaryotic messenger RNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyadenylation at the 3′-end. Despite the characterization of many proteins… Expand
The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.
Cleavage-polyadenylation specificity factor (CPSF) is a multisubunit protein that plays a central role in 3' processing of mammalian pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and… Expand
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Alternative splicing of mRNA precursors provides an important means of genetic control and is a crucial step in the expression of most genes. Alternative splicing markedly affects human development,… Expand
Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability
SR proteins constitute a family of pre-mRNA splicing factors now thought to play several roles in mRNA metabolism in metazoan cells. Here we provide evidence that a prototypical SR protein, ASF/SF2,… Expand
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
Mammalian Clk/Sty is the prototype for a family of dual specificity kinases (termed LAMMER kinases) that have been conserved in evolution, but whose physiological substrates are unknown. In a yeast… Expand
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to both innate and adaptive immunity for host defence. These receptors share a conserved cytoplasmic… Expand
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.
ASF/SF2 and SC35 belong to a highly conserved family of nuclear proteins that are both essential for splicing of pre‐mRNA in vitro and are able to influence selection of alternative splice sites. An… Expand
Mechanism and regulation of mRNA polyadenylation.
A poly(A) tail is found at the 38 end of nearly every fully processed eukaryotic mRNA and has been suggested to influence virtually all aspects of mRNA metabolism. Its proposed functions include… Expand
Mechanisms and consequences of alternative polyadenylation.
Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode… Expand