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H2AFX wt Allele

Known as: H2A.X, H2AX, H2AFX 
Human H2AFX wild-type allele is located within 11q23.2-q23.3 and is approximately 2 kb in length. This allele, which encodes histone H2A.x protein… 
National Institutes of Health

Related topics

Related topics

6 relations
11q23.2-q23.3Double Strand Break RepairH2AFX geneH2AX protein, human

Papers overview

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2016
2016
γ-H2AX responds to DNA damage induced by long-term exposure to combined low-dose-rate neutron and γ-ray radiation.
Highly Cited
2014
Highly Cited
2014
Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair
The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local activation of DNA-damage repair pathways… 
Highly Cited
2012
Highly Cited
2012
BCLAF1 is a radiation-induced H2AX-interacting partner involved in γH2AX-mediated regulation of apoptosis and DNA repair
H2AX, a histone H2A variant, has a key role in the cellular response to DNA double-strand breaks (DSBs). H2AX senses DSBs through… 
Highly Cited
2012
Highly Cited
2012
Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells
Phosphorylation of the histone variant H2AX forms γ-H2AX that marks DNA double-strand break (DSB). Here, we generated the… 
Highly Cited
2009
Highly Cited
2009
ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress*
Chromosomal abnormalities are frequently caused by problems encountered during DNA replication. Although the ATR-Chk1 pathway has… 
Highly Cited
2009
Highly Cited
2009
Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family.
2008
2008
Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis
BackgroundChromatin-associated histone H2AX is a key regulator of the cellular responses to DNA damage. However, non-nucleosomal… 
Highly Cited
2007
Highly Cited
2007
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.
2007
2007
Inhibition of transcription at radiation-induced nuclear foci of phosphorylated histone H2AX in mammalian cells
Double-strand DNA breaks (DSBs) induced by ionizing radiation can be visualized in human cells using antibodies against Ser-139… 
Review
2004
Review
2004
H2AX May Function as an Anchor to Hold Broken Chromosomal DNA Ends in Close Proximity
The histone H2A variant, H2AX, is a core component of chromatin that is phosphorylated in chromatin flanking DNA double strand… 
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